RABGEF1 protein (Canis lupus familiaris) - STRING interaction network

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Score

RABGEF1

RAB guanine nucleotide exchange factor 1. (784 aa)

Predicted Functional Partners:

RAB5A

0.981

RAB5C

0.981

RABEP1

0.978

RAB5B

0.970

RABEP2

0.920

RAB24

0.911

RAB17

0.908

RAB22A

0.887

ZHX2

0.884

RAB20

0.884

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RAB17	RABEP1	ENSCAFP00000059709	ENSCAFP00000022927	RAB17, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 1.	0.770
RAB17	RABEP2	ENSCAFP00000059709	ENSCAFP00000056258	RAB17, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 2.	0.439
RAB17	RABGEF1	ENSCAFP00000059709	ENSCAFP00000015865	RAB17, member RAS oncogene family.	RAB guanine nucleotide exchange factor 1.	0.908
RAB20	RAB24	ENSCAFP00000009116	ENSCAFP00000024213	RAB20, member RAS oncogene family.	RAB24, member RAS oncogene family.	0.517
RAB20	RAB5A	ENSCAFP00000009116	ENSCAFP00000008690	RAB20, member RAS oncogene family.	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]	0.533
RAB20	RAB5C	ENSCAFP00000009116	ENSCAFP00000022977	RAB20, member RAS oncogene family.	Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.	0.535
RAB20	RABEP1	ENSCAFP00000009116	ENSCAFP00000022927	RAB20, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 1.	0.422
RAB20	RABEP2	ENSCAFP00000009116	ENSCAFP00000056258	RAB20, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 2.	0.422
RAB20	RABGEF1	ENSCAFP00000009116	ENSCAFP00000015865	RAB20, member RAS oncogene family.	RAB guanine nucleotide exchange factor 1.	0.884
RAB22A	RABEP1	ENSCAFP00000064006	ENSCAFP00000022927	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	Rabaptin, RAB GTPase binding effector protein 1.	0.451
RAB22A	RABEP2	ENSCAFP00000064006	ENSCAFP00000056258	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	Rabaptin, RAB GTPase binding effector protein 2.	0.422
RAB22A	RABGEF1	ENSCAFP00000064006	ENSCAFP00000015865	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	RAB guanine nucleotide exchange factor 1.	0.887
RAB24	RAB20	ENSCAFP00000024213	ENSCAFP00000009116	RAB24, member RAS oncogene family.	RAB20, member RAS oncogene family.	0.517
RAB24	RAB5A	ENSCAFP00000024213	ENSCAFP00000008690	RAB24, member RAS oncogene family.	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]	0.543
RAB24	RAB5C	ENSCAFP00000024213	ENSCAFP00000022977	RAB24, member RAS oncogene family.	Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.	0.543
RAB24	RABEP1	ENSCAFP00000024213	ENSCAFP00000022927	RAB24, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 1.	0.490
RAB24	RABEP2	ENSCAFP00000024213	ENSCAFP00000056258	RAB24, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 2.	0.422
RAB24	RABGEF1	ENSCAFP00000024213	ENSCAFP00000015865	RAB24, member RAS oncogene family.	RAB guanine nucleotide exchange factor 1.	0.911
RAB5A	RAB20	ENSCAFP00000008690	ENSCAFP00000009116	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]	RAB20, member RAS oncogene family.	0.533
RAB5A	RAB24	ENSCAFP00000008690	ENSCAFP00000024213	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]	RAB24, member RAS oncogene family.	0.543