IPO8 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

IPO8

Importin 8. (1037 aa)

Predicted Functional Partners:

IPO9

0.959

IPO5

0.952

IPO4

0.952

KPNB1

0.949

TNPO1

0.944

RANBP6

0.934

TNPO2

0.923

IPO13

0.902

LOC100686305

0.894

TNPO3

0.884

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IPO13	IPO4	ENSCAFP00000050866	ENSCAFP00000017742	Importin 13.	Importin 4.	0.924
IPO13	IPO5	ENSCAFP00000050866	ENSCAFP00000008328	Importin 13.	Importin 5.	0.959
IPO13	IPO8	ENSCAFP00000050866	ENSCAFP00000015868	Importin 13.	Importin 8.	0.902
IPO13	IPO9	ENSCAFP00000050866	ENSCAFP00000064155	Importin 13.	Importin 9.	0.948
IPO13	KPNB1	ENSCAFP00000050866	ENSCAFP00000044873	Importin 13.	Karyopherin subunit beta 1.	0.887
IPO13	LOC100686305	ENSCAFP00000050866	ENSCAFP00000048537	Importin 13.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.751
IPO13	RANBP6	ENSCAFP00000050866	ENSCAFP00000049559	Importin 13.	Uncharacterized protein.	0.789
IPO13	TNPO1	ENSCAFP00000050866	ENSCAFP00000011990	Importin 13.	Transportin 1.	0.908
IPO13	TNPO2	ENSCAFP00000050866	ENSCAFP00000051986	Importin 13.	Transportin 2.	0.913
IPO13	TNPO3	ENSCAFP00000050866	ENSCAFP00000002231	Importin 13.	Transportin 3.	0.892
IPO4	IPO13	ENSCAFP00000017742	ENSCAFP00000050866	Importin 4.	Importin 13.	0.924
IPO4	IPO5	ENSCAFP00000017742	ENSCAFP00000008328	Importin 4.	Importin 5.	0.967
IPO4	IPO8	ENSCAFP00000017742	ENSCAFP00000015868	Importin 4.	Importin 8.	0.952
IPO4	IPO9	ENSCAFP00000017742	ENSCAFP00000064155	Importin 4.	Importin 9.	0.965
IPO4	KPNB1	ENSCAFP00000017742	ENSCAFP00000044873	Importin 4.	Karyopherin subunit beta 1.	0.976
IPO4	LOC100686305	ENSCAFP00000017742	ENSCAFP00000048537	Importin 4.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.550
IPO4	TNPO1	ENSCAFP00000017742	ENSCAFP00000011990	Importin 4.	Transportin 1.	0.963
IPO4	TNPO2	ENSCAFP00000017742	ENSCAFP00000051986	Importin 4.	Transportin 2.	0.954
IPO4	TNPO3	ENSCAFP00000017742	ENSCAFP00000002231	Importin 4.	Transportin 3.	0.881
IPO5	IPO13	ENSCAFP00000008328	ENSCAFP00000050866	Importin 5.	Importin 13.	0.959