TIGIT protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

TIGIT

T cell immunoreceptor with Ig and ITIM domains. (315 aa)

Predicted Functional Partners:

NECTIN2

0.997

PVR

0.996

NECTIN3

0.959

LAG3

0.878

CD274

0.801

CTLA4

0.782

LGALS9

0.731

TNFRSF18

0.715

ICOS

0.699

FOXP3

0.689

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD274	CTLA4	ENSCAFP00000003106	ENSCAFP00000018967	Programmed death ligand 1.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.959
CD274	FOXP3	ENSCAFP00000003106	ENSCAFP00000023435	Programmed death ligand 1.	Forkhead box P3.	0.827
CD274	ICOS	ENSCAFP00000003106	ENSCAFP00000018974	Programmed death ligand 1.	Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]	0.775
CD274	LAG3	ENSCAFP00000003106	ENSCAFP00000021640	Programmed death ligand 1.	Lymphocyte activating 3.	0.828
CD274	LGALS9	ENSCAFP00000003106	ENSCAFP00000049198	Programmed death ligand 1.	Galectin.	0.742
CD274	TIGIT	ENSCAFP00000003106	ENSCAFP00000015906	Programmed death ligand 1.	T cell immunoreceptor with Ig and ITIM domains.	0.801
CD274	TNFRSF18	ENSCAFP00000003106	ENSCAFP00000028538	Programmed death ligand 1.	TNF receptor superfamily member 18.	0.412
CTLA4	CD274	ENSCAFP00000018967	ENSCAFP00000003106	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Programmed death ligand 1.	0.959
CTLA4	FOXP3	ENSCAFP00000018967	ENSCAFP00000023435	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Forkhead box P3.	0.857
CTLA4	ICOS	ENSCAFP00000018967	ENSCAFP00000018974	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]	0.897
CTLA4	LAG3	ENSCAFP00000018967	ENSCAFP00000021640	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Lymphocyte activating 3.	0.904
CTLA4	LGALS9	ENSCAFP00000018967	ENSCAFP00000049198	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Galectin.	0.653
CTLA4	NECTIN2	ENSCAFP00000018967	ENSCAFP00000006905	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Nectin cell adhesion molecule 2.	0.516
CTLA4	PVR	ENSCAFP00000018967	ENSCAFP00000006945	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	PVR cell adhesion molecule.	0.407
CTLA4	TIGIT	ENSCAFP00000018967	ENSCAFP00000015906	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	T cell immunoreceptor with Ig and ITIM domains.	0.782
CTLA4	TNFRSF18	ENSCAFP00000018967	ENSCAFP00000028538	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	TNF receptor superfamily member 18.	0.591
FOXP3	CD274	ENSCAFP00000023435	ENSCAFP00000003106	Forkhead box P3.	Programmed death ligand 1.	0.827
FOXP3	CTLA4	ENSCAFP00000023435	ENSCAFP00000018967	Forkhead box P3.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.857
FOXP3	ICOS	ENSCAFP00000023435	ENSCAFP00000018974	Forkhead box P3.	Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]	0.830
FOXP3	LAG3	ENSCAFP00000023435	ENSCAFP00000021640	Forkhead box P3.	Lymphocyte activating 3.	0.772