TIGIT protein (Canis lupus familiaris) - STRING interaction network

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Score

TIGIT

T cell immunoreceptor with Ig and ITIM domains. (315 aa)

Predicted Functional Partners:

NECTIN2

0.994

PVR

0.990

NECTIN3

0.961

LAG3

0.885

CTLA4

0.855

PDCD1

0.769

CD274

0.767

HAVCR1

0.765

ICOS

0.737

CD226

0.734

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD226	CTLA4	ENSCAFP00000039866	ENSCAFP00000018967	CD226 molecule.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.490
CD226	NECTIN2	ENSCAFP00000039866	ENSCAFP00000006905	CD226 molecule.	Nectin cell adhesion molecule 2.	0.999
CD226	PVR	ENSCAFP00000039866	ENSCAFP00000006945	CD226 molecule.	PVR cell adhesion molecule.	0.998
CD226	TIGIT	ENSCAFP00000039866	ENSCAFP00000015906	CD226 molecule.	T cell immunoreceptor with Ig and ITIM domains.	0.734
CD274	CTLA4	ENSCAFP00000003106	ENSCAFP00000018967	Programmed death ligand 1.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.900
CD274	HAVCR1	ENSCAFP00000003106	ENSCAFP00000025920	Programmed death ligand 1.	Ig-like domain-containing protein.	0.568
CD274	ICOS	ENSCAFP00000003106	ENSCAFP00000018974	Programmed death ligand 1.	Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]	0.728
CD274	LAG3	ENSCAFP00000003106	ENSCAFP00000021640	Programmed death ligand 1.	Lymphocyte activating 3.	0.854
CD274	PDCD1	ENSCAFP00000003106	ENSCAFP00000019435	Programmed death ligand 1.	Programmed cell death 1.	0.998
CD274	TIGIT	ENSCAFP00000003106	ENSCAFP00000015906	Programmed death ligand 1.	T cell immunoreceptor with Ig and ITIM domains.	0.767
CTLA4	CD226	ENSCAFP00000018967	ENSCAFP00000039866	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	CD226 molecule.	0.490
CTLA4	CD274	ENSCAFP00000018967	ENSCAFP00000003106	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Programmed death ligand 1.	0.900
CTLA4	HAVCR1	ENSCAFP00000018967	ENSCAFP00000025920	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Ig-like domain-containing protein.	0.638
CTLA4	ICOS	ENSCAFP00000018967	ENSCAFP00000018974	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]	0.873
CTLA4	LAG3	ENSCAFP00000018967	ENSCAFP00000021640	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Lymphocyte activating 3.	0.891
CTLA4	PDCD1	ENSCAFP00000018967	ENSCAFP00000019435	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Programmed cell death 1.	0.928
CTLA4	TIGIT	ENSCAFP00000018967	ENSCAFP00000015906	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	T cell immunoreceptor with Ig and ITIM domains.	0.855
HAVCR1	CD274	ENSCAFP00000025920	ENSCAFP00000003106	Ig-like domain-containing protein.	Programmed death ligand 1.	0.568
HAVCR1	CTLA4	ENSCAFP00000025920	ENSCAFP00000018967	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.638
HAVCR1	ICOS	ENSCAFP00000025920	ENSCAFP00000018974	Ig-like domain-containing protein.	Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]	0.459