Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
NKD2NKD inhibitor of WNT signaling pathway 2. (560 aa)    
Predicted Functional Partners:
DVL1
Dishevelled segment polarity protein 1.
    
 0.969
DVL2
Dishevelled segment polarity protein 2.
    
 0.959
DVL3
Dishevelled segment polarity protein 3.
    
 0.944
NKD1
NKD inhibitor of WNT signaling pathway 1.
     
 0.885
ENSCAFP00000046000
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
    
   0.775
YWHAE
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family.
    
   0.775
ENSCAFP00000047349
Uncharacterized protein.
    
   0.694
LOC485223
Olfactory receptor.
   
  
 0.679
WNT9A
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
    
 
 0.611
FRZB
Frizzled related protein.
    
 
 0.607
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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