STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPP6R3Protein phosphatase 6 regulatory subunit 3. (897 aa)    
Predicted Functional Partners:
PPP6C
Serine/threonine-protein phosphatase.
    
 0.955
ANKRD28
Ankyrin repeat domain 28.
    
 0.943
ANKRD52
Ankyrin repeat domain 52.
    
 
 0.735
PPP6C-2
Protein phosphatase 6 catalytic subunit.
    
 
 0.667
CCDC158
Coiled-coil domain containing 158.
    
 
 0.664
TXLNB
Taxilin beta.
      
 0.645
TMEM236
Transmembrane protein 236.
      
 0.641
MASTL
Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...]
      
 0.640
ALMS1
ALMS1 centrosome and basal body associated protein.
      
 0.638
ANKRD44
Ankyrin repeat domain 44.
    
 
 0.635
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.