STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAP43Growth associated protein 43. (291 aa)    
Predicted Functional Partners:
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.
   
  
 0.855
NGF
Nerve growth factor; Belongs to the NGF-beta family.
      
 0.847
LYPLA2
PITH domain containing 1.
     
 0.781
SYP
Synaptophysin.
   
  
 0.744
MAP2
Microtubule-associated protein.
   
 
 0.735
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
  
 0.729
ATF3
Activating transcription factor 3.
   
  
 0.721
BDNF
Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]
   
  
 0.708
STMN2
Stathmin 2.
   
  
 0.692
ATOH7
Atonal bHLH transcription factor 7.
      
 0.688
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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