TET2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TET2

Tet methylcytosine dioxygenase 2. (2018 aa)

Predicted Functional Partners:

OGT

0.889

DNMT3A

0.863

DNMT1

0.836

GPR84

0.808

ARID4B

0.741

GRIA2

0.692

EZH2

0.691

IDH2

0.689

IDH1

0.679

GASK1B

0.675

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4B	GASK1B	ENSCAFP00000016861	ENSCAFP00000037402	AT-rich interaction domain 4B.	Golgi associated kinase 1B.	0.420
ARID4B	GPR84	ENSCAFP00000016861	ENSCAFP00000009750	AT-rich interaction domain 4B.	G protein-coupled receptor 84.	0.812
ARID4B	OGT	ENSCAFP00000016861	ENSCAFP00000025249	AT-rich interaction domain 4B.	O-linked N-acetylglucosamine (GlcNAc) transferase.	0.508
ARID4B	TET2	ENSCAFP00000016861	ENSCAFP00000015986	AT-rich interaction domain 4B.	Tet methylcytosine dioxygenase 2.	0.741
DNMT1	DNMT3A	ENSCAFP00000026412	ENSCAFP00000006185	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.999
DNMT1	EZH2	ENSCAFP00000026412	ENSCAFP00000036992	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.990
DNMT1	TET2	ENSCAFP00000026412	ENSCAFP00000015986	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 2.	0.836
DNMT3A	DNMT1	ENSCAFP00000006185	ENSCAFP00000026412	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.999
DNMT3A	EZH2	ENSCAFP00000006185	ENSCAFP00000036992	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.966
DNMT3A	IDH1	ENSCAFP00000006185	ENSCAFP00000020046	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.556
DNMT3A	IDH2	ENSCAFP00000006185	ENSCAFP00000063101	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.558
DNMT3A	TET2	ENSCAFP00000006185	ENSCAFP00000015986	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 2.	0.863
EZH2	DNMT1	ENSCAFP00000036992	ENSCAFP00000026412	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.990
EZH2	DNMT3A	ENSCAFP00000036992	ENSCAFP00000006185	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.966
EZH2	IDH1	ENSCAFP00000036992	ENSCAFP00000020046	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.472
EZH2	IDH2	ENSCAFP00000036992	ENSCAFP00000063101	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.478
EZH2	TET2	ENSCAFP00000036992	ENSCAFP00000015986	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Tet methylcytosine dioxygenase 2.	0.691
GASK1B	ARID4B	ENSCAFP00000037402	ENSCAFP00000016861	Golgi associated kinase 1B.	AT-rich interaction domain 4B.	0.420
GASK1B	GRIA2	ENSCAFP00000037402	ENSCAFP00000055411	Golgi associated kinase 1B.	Glutamate ionotropic receptor AMPA type subunit 2.	0.410
GASK1B	TET2	ENSCAFP00000037402	ENSCAFP00000015986	Golgi associated kinase 1B.	Tet methylcytosine dioxygenase 2.	0.675