STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RFTN2Raftlin family member 2. (507 aa)    
Predicted Functional Partners:
ARL6IP6
ADP ribosylation factor like GTPase 6 interacting protein 6.
      
 0.894
PLBD2
Phospholipase B-like; Putative phospholipase.
      
 0.889
N6AMT1
N-6 adenine-specific DNA methyltransferase 1.
      
 0.877
NUGGC
Nuclear GTPase, germinal center associated.
      
 0.552
BMT2
S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]
      
 0.524
SDSL
Serine dehydratase like.
      
 0.519
CLIC3
Chloride intracellular channel 3.
      
 0.490
MOSPD2
Motile sperm domain containing 2.
      
 0.474
OTOP1
Otopetrin 1.
      
 0.468
AKAP6
A-kinase anchoring protein 6.
      
 0.427
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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