CD80 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

CD80

CD80 molecule. (304 aa)

Predicted Functional Partners:

CD28

0.998

CTLA4

0.993

CD86

0.975

CD274

0.965

CD40

0.955

CD4

0.933

CD83

0.925

IFNG

0.896

IL10

0.896

FOXP3

0.878

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD274	CD28	ENSCAFP00000003106	ENSCAFP00000052654	Programmed death ligand 1.	CD28 molecule.	0.744
CD274	CD4	ENSCAFP00000003106	ENSCAFP00000063394	Programmed death ligand 1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.889
CD274	CD40	ENSCAFP00000003106	ENSCAFP00000061346	Programmed death ligand 1.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.695
CD274	CD80	ENSCAFP00000003106	ENSCAFP00000016197	Programmed death ligand 1.	CD80 molecule.	0.965
CD274	CD83	ENSCAFP00000003106	ENSCAFP00000056788	Programmed death ligand 1.	CD83 molecule.	0.492
CD274	CD86	ENSCAFP00000003106	ENSCAFP00000017296	Programmed death ligand 1.	CD86 molecule.	0.652
CD274	CTLA4	ENSCAFP00000003106	ENSCAFP00000018967	Programmed death ligand 1.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.900
CD274	FOXP3	ENSCAFP00000003106	ENSCAFP00000023435	Programmed death ligand 1.	Forkhead box P3.	0.822
CD274	IFNG	ENSCAFP00000003106	ENSCAFP00000000588	Programmed death ligand 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.868
CD274	IL10	ENSCAFP00000003106	ENSCAFP00000016812	Programmed death ligand 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.800
CD28	CD274	ENSCAFP00000052654	ENSCAFP00000003106	CD28 molecule.	Programmed death ligand 1.	0.744
CD28	CD4	ENSCAFP00000052654	ENSCAFP00000063394	CD28 molecule.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.859
CD28	CD40	ENSCAFP00000052654	ENSCAFP00000061346	CD28 molecule.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.524
CD28	CD80	ENSCAFP00000052654	ENSCAFP00000016197	CD28 molecule.	CD80 molecule.	0.998
CD28	CD86	ENSCAFP00000052654	ENSCAFP00000017296	CD28 molecule.	CD86 molecule.	0.995
CD28	CTLA4	ENSCAFP00000052654	ENSCAFP00000018967	CD28 molecule.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.694
CD28	FOXP3	ENSCAFP00000052654	ENSCAFP00000023435	CD28 molecule.	Forkhead box P3.	0.731
CD28	IFNG	ENSCAFP00000052654	ENSCAFP00000000588	CD28 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.797
CD28	IL10	ENSCAFP00000052654	ENSCAFP00000016812	CD28 molecule.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.675
CD4	CD274	ENSCAFP00000063394	ENSCAFP00000003106	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Programmed death ligand 1.	0.889