HEPACAM protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HEPACAM

Hepatic and glial cell adhesion molecule. (418 aa)

Predicted Functional Partners:

SPRED1

0.710

MCPH1

0.689

PLP1

0.593

OFD1

0.590

GPC3

0.580

ASPM

0.579

GALC

0.575

GSE1

0.545

SERPINB12

0.544

DNMT3A

0.534

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPM	GPC3	ENSCAFP00000016776	ENSCAFP00000027825	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.526
ASPM	HEPACAM	ENSCAFP00000016776	ENSCAFP00000016213	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Hepatic and glial cell adhesion molecule.	0.579
ASPM	MCPH1	ENSCAFP00000016776	ENSCAFP00000012590	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Microcephalin 1.	0.944
ASPM	OFD1	ENSCAFP00000016776	ENSCAFP00000059196	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	OFD1 centriole and centriolar satellite protein.	0.530
ASPM	SPRED1	ENSCAFP00000016776	ENSCAFP00000047550	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Sprouty related EVH1 domain containing 1.	0.574
DNMT3A	HEPACAM	ENSCAFP00000006185	ENSCAFP00000016213	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Hepatic and glial cell adhesion molecule.	0.534
GALC	HEPACAM	ENSCAFP00000031633	ENSCAFP00000016213	Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family.	Hepatic and glial cell adhesion molecule.	0.575
GALC	PLP1	ENSCAFP00000031633	ENSCAFP00000065483	Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family.	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.	0.576
GPC3	ASPM	ENSCAFP00000027825	ENSCAFP00000016776	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	0.526
GPC3	HEPACAM	ENSCAFP00000027825	ENSCAFP00000016213	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Hepatic and glial cell adhesion molecule.	0.580
GPC3	MCPH1	ENSCAFP00000027825	ENSCAFP00000012590	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Microcephalin 1.	0.642
GPC3	OFD1	ENSCAFP00000027825	ENSCAFP00000059196	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	OFD1 centriole and centriolar satellite protein.	0.699
GPC3	SPRED1	ENSCAFP00000027825	ENSCAFP00000047550	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Sprouty related EVH1 domain containing 1.	0.568
GSE1	HEPACAM	ENSCAFP00000049869	ENSCAFP00000016213	Gse1 coiled-coil protein.	Hepatic and glial cell adhesion molecule.	0.545
HEPACAM	ASPM	ENSCAFP00000016213	ENSCAFP00000016776	Hepatic and glial cell adhesion molecule.	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	0.579
HEPACAM	DNMT3A	ENSCAFP00000016213	ENSCAFP00000006185	Hepatic and glial cell adhesion molecule.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.534
HEPACAM	GALC	ENSCAFP00000016213	ENSCAFP00000031633	Hepatic and glial cell adhesion molecule.	Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family.	0.575
HEPACAM	GPC3	ENSCAFP00000016213	ENSCAFP00000027825	Hepatic and glial cell adhesion molecule.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.580
HEPACAM	GSE1	ENSCAFP00000016213	ENSCAFP00000049869	Hepatic and glial cell adhesion molecule.	Gse1 coiled-coil protein.	0.545
HEPACAM	MCPH1	ENSCAFP00000016213	ENSCAFP00000012590	Hepatic and glial cell adhesion molecule.	Microcephalin 1.	0.689