STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
COX17Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). (63 aa)    
Predicted Functional Partners:
CHCHD4
Coiled-coil-helix-coiled-coil-helix domain containing 4.
   
 
 0.957
ATOX1
Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.
   
 
 0.917
CCS
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
   
 
 0.908
COX11
Cytochrome c oxidase copper chaperone COX11.
   
  
 0.892
SCO2
SCO cytochrome c oxidase assembly protein 2.
    
 
 0.891
SCO1
SCO cytochrome c oxidase assembly protein 1.
   
 
 0.874
ATP7A
ATPase copper transporting alpha.
   
  
 0.873
ATP7B
ATPase copper transporting beta.
      
 0.870
LOC611632
Uncharacterized protein; Belongs to the multicopper oxidase family.
      
 0.815
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
      
 0.815
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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