CRLF2 protein (Canis lupus familiaris) - STRING interaction network

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Score

CRLF2

Cytokine receptor like factor 2. (373 aa)

Predicted Functional Partners:

IL7R

0.993

TSLP

0.993

GTPBP6

0.859

JAK2

0.812

DHRSX

0.803

IL7

0.770

JAK3

0.760

JAK1

0.759

IL4

0.732

TYK2

0.726

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRLF2	DHRSX	ENSCAFP00000016256	ENSCAFP00000016307	Cytokine receptor like factor 2.	Dehydrogenase/reductase X-linked.	0.803
CRLF2	GTPBP6	ENSCAFP00000016256	ENSCAFP00000058126	Cytokine receptor like factor 2.	GTP binding protein 6 (putative).	0.859
CRLF2	IL4	ENSCAFP00000016256	ENSCAFP00000001253	Cytokine receptor like factor 2.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.732
CRLF2	IL7	ENSCAFP00000016256	ENSCAFP00000012305	Cytokine receptor like factor 2.	Interleukin 7.	0.770
CRLF2	IL7R	ENSCAFP00000016256	ENSCAFP00000027663	Cytokine receptor like factor 2.	Interleukin 7 receptor.	0.993
CRLF2	JAK1	ENSCAFP00000016256	ENSCAFP00000039978	Cytokine receptor like factor 2.	Tyrosine-protein kinase.	0.759
CRLF2	JAK2	ENSCAFP00000016256	ENSCAFP00000044346	Cytokine receptor like factor 2.	Janus kinase 2.	0.812
CRLF2	JAK3	ENSCAFP00000016256	ENSCAFP00000041505	Cytokine receptor like factor 2.	Tyrosine-protein kinase.	0.760
CRLF2	TSLP	ENSCAFP00000016256	ENSCAFP00000040916	Cytokine receptor like factor 2.	Thymic stromal lymphopoietin.	0.993
CRLF2	TYK2	ENSCAFP00000016256	ENSCAFP00000050119	Cytokine receptor like factor 2.	Tyrosine-protein kinase.	0.726
DHRSX	CRLF2	ENSCAFP00000016307	ENSCAFP00000016256	Dehydrogenase/reductase X-linked.	Cytokine receptor like factor 2.	0.803
DHRSX	GTPBP6	ENSCAFP00000016307	ENSCAFP00000058126	Dehydrogenase/reductase X-linked.	GTP binding protein 6 (putative).	0.879
GTPBP6	CRLF2	ENSCAFP00000058126	ENSCAFP00000016256	GTP binding protein 6 (putative).	Cytokine receptor like factor 2.	0.859
GTPBP6	DHRSX	ENSCAFP00000058126	ENSCAFP00000016307	GTP binding protein 6 (putative).	Dehydrogenase/reductase X-linked.	0.879
IL4	CRLF2	ENSCAFP00000001253	ENSCAFP00000016256	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Cytokine receptor like factor 2.	0.732
IL4	IL7	ENSCAFP00000001253	ENSCAFP00000012305	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Interleukin 7.	0.897
IL4	IL7R	ENSCAFP00000001253	ENSCAFP00000027663	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Interleukin 7 receptor.	0.803
IL4	JAK1	ENSCAFP00000001253	ENSCAFP00000039978	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Tyrosine-protein kinase.	0.971
IL4	JAK2	ENSCAFP00000001253	ENSCAFP00000044346	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Janus kinase 2.	0.846
IL4	JAK3	ENSCAFP00000001253	ENSCAFP00000041505	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Tyrosine-protein kinase.	0.976