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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMCO2Single-pass membrane protein with coiled-coil domains 2. (370 aa)    
Predicted Functional Partners:
ARNTL2
Aryl hydrocarbon receptor nuclear translocator like 2.
      
 0.793
PPFIBP1
PPFIA binding protein 1.
      
 0.783
MOB2
MOB kinase activator 2.
      
 0.688
ASAH2
Neutral ceramidase.
      
 0.671
OSBPL8
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.570
GBE1
1,4-alpha-glucan branching enzyme 1.
      
 0.566
STK38L
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
      
 0.563
CA12
Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family.
      
 0.403
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.