STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG4BPleckstrin homology and RhoGEF domain containing G4B. (1534 aa)    
Predicted Functional Partners:
UNC80
Unc-80 homolog, NALCN channel complex subunit.
    
 
 0.687
UNC79
Unc-79 homolog, NALCN channel complex subunit.
      
 0.606
NALCN
Sodium leak channel, non-selective.
      
 0.596
ARHGEF11
Rho guanine nucleotide exchange factor 11.
      
 0.580
PCYT2
Phosphate cytidylyltransferase 2, ethanolamine.
      
 0.538
ECT2L
Epithelial cell transforming 2 like.
    
 
 0.536
PPWD1
Peptidylprolyl isomerase domain and WD repeat containing 1.
      
 0.486
ARHGEF19
Rho guanine nucleotide exchange factor 19.
      
 0.473
ARHGEF33
Rho guanine nucleotide exchange factor 33.
   
  
 0.471
CNN1
Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
    
 
 0.469
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.