STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ROBO4Roundabout guidance receptor 4. (1043 aa)    
Predicted Functional Partners:
SLIT2
Slit guidance ligand 2.
   
 
 0.903
SLIT1
Slit guidance ligand 1.
   
 
 0.833
UNC5B
Unc-5 netrin receptor B.
      
0.743
SLIT3
Slit guidance ligand 3.
   
 
 0.741
CLDN5
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.737
EMCN
Endomucin.
   
  
 0.716
GIT1
GIT ArfGAP 1.
      
 0.704
PXN
Paxillin.
   
  
 0.698
MMRN2
Multimerin 2.
   
 
 0.679
SOX18
SRY-box 18.
   
  
 0.639
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.