STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMZ2Archaelysin family metallopeptidase 2. (360 aa)    
Predicted Functional Partners:
THBS2
Thrombospondin 2.
      
 0.616
ST14
Suppression of tumorigenicity 14.
      
 0.592
CDH20
Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.
      
 0.553
ENSCAFP00000055086
Uncharacterized protein.
      
 0.547
NHSL1
NHS like 1.
    
   0.501
CYFIP1
Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.
    
   0.500
DFFB
DNA fragmentation factor subunit beta.
      
 0.475
LGALS3
Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage [...]
   
  
 0.435
ABITRAM
Actin binding transcription modulator.
      
 0.435
NIPAL3
NIPA like domain containing 3.
      
 0.428
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.