PDE6D protein (Canis lupus familiaris) - STRING interaction network

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PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...] (150 aa)

Predicted Functional Partners:

ARL3

0.985

INPP5E

0.984

RPGR

0.954

ARL13B

0.931

ARL2

0.915

GUCY1B1

0.906

F1PIP2_CANLF

0.900

ARL16

0.891

GMPR2

0.887

ADCY8

0.884

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	PDE6D	ENSCAFP00000001538	ENSCAFP00000016354	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.884
ARL13B	ARL16	ENSCAFP00000013262	ENSCAFP00000033990	ADP ribosylation factor like GTPase 13B.	ADP ribosylation factor like GTPase 16.	0.453
ARL13B	ARL3	ENSCAFP00000013262	ENSCAFP00000047245	ADP ribosylation factor like GTPase 13B.	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	0.594
ARL13B	INPP5E	ENSCAFP00000013262	ENSCAFP00000029099	ADP ribosylation factor like GTPase 13B.	Inositol polyphosphate-5-phosphatase E.	0.949
ARL13B	PDE6D	ENSCAFP00000013262	ENSCAFP00000016354	ADP ribosylation factor like GTPase 13B.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.931
ARL16	ARL13B	ENSCAFP00000033990	ENSCAFP00000013262	ADP ribosylation factor like GTPase 16.	ADP ribosylation factor like GTPase 13B.	0.453
ARL16	PDE6D	ENSCAFP00000033990	ENSCAFP00000016354	ADP ribosylation factor like GTPase 16.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.891
ARL2	PDE6D	ENSCAFP00000035998	ENSCAFP00000016354	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.915
ARL3	ARL13B	ENSCAFP00000047245	ENSCAFP00000013262	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	ADP ribosylation factor like GTPase 13B.	0.594
ARL3	INPP5E	ENSCAFP00000047245	ENSCAFP00000029099	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Inositol polyphosphate-5-phosphatase E.	0.457
ARL3	PDE6D	ENSCAFP00000047245	ENSCAFP00000016354	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.985
ARL3	RPGR	ENSCAFP00000047245	ENSCAFP00000037530	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	X-linked retinitis pigmentosa GTPase regulator; Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes.	0.572
F1PIP2_CANLF	GUCY1B1	ENSCAFP00000006376	ENSCAFP00000059398	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.	0.967
F1PIP2_CANLF	PDE6D	ENSCAFP00000006376	ENSCAFP00000016354	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.900
GMPR2	PDE6D	ENSCAFP00000017919	ENSCAFP00000016354	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.887
GUCY1B1	F1PIP2_CANLF	ENSCAFP00000059398	ENSCAFP00000006376	Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.967
GUCY1B1	PDE6D	ENSCAFP00000059398	ENSCAFP00000016354	Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.906
INPP5E	ARL13B	ENSCAFP00000029099	ENSCAFP00000013262	Inositol polyphosphate-5-phosphatase E.	ADP ribosylation factor like GTPase 13B.	0.949
INPP5E	ARL3	ENSCAFP00000029099	ENSCAFP00000047245	Inositol polyphosphate-5-phosphatase E.	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	0.457
INPP5E	PDE6D	ENSCAFP00000029099	ENSCAFP00000016354	Inositol polyphosphate-5-phosphatase E.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]	0.984

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