ACACB protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ACACB

Acetyl-CoA carboxylase beta. (2431 aa)

Predicted Functional Partners:

FASN

0.942

ACLY

0.918

ACSS2

0.918

PRKAB1

0.892

LOC100856570

0.883

LOC487740

0.883

MCAT

0.882

HLCS

0.878

PRKAB2

0.876

PRKAA1

0.860

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ACLY	ENSCAFP00000016357	ENSCAFP00000023291	Acetyl-CoA carboxylase beta.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.918
ACACB	ACSS2	ENSCAFP00000016357	ENSCAFP00000065471	Acetyl-CoA carboxylase beta.	Acyl-CoA synthetase short chain family member 2.	0.918
ACACB	FASN	ENSCAFP00000016357	ENSCAFP00000009039	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.942
ACACB	HLCS	ENSCAFP00000016357	ENSCAFP00000014244	Acetyl-CoA carboxylase beta.	Holocarboxylase synthetase.	0.878
ACACB	LOC100856570	ENSCAFP00000016357	ENSCAFP00000013625	Acetyl-CoA carboxylase beta.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.883
ACACB	LOC487740	ENSCAFP00000016357	ENSCAFP00000036914	Acetyl-CoA carboxylase beta.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.883
ACACB	MCAT	ENSCAFP00000016357	ENSCAFP00000001310	Acetyl-CoA carboxylase beta.	Malonyl-CoA-acyl carrier protein transacylase.	0.882
ACACB	PRKAA1	ENSCAFP00000016357	ENSCAFP00000050809	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.860
ACACB	PRKAB1	ENSCAFP00000016357	ENSCAFP00000049890	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.892
ACACB	PRKAB2	ENSCAFP00000016357	ENSCAFP00000039462	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.876
ACLY	ACACB	ENSCAFP00000023291	ENSCAFP00000016357	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyl-CoA carboxylase beta.	0.918
ACLY	ACSS2	ENSCAFP00000023291	ENSCAFP00000065471	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acyl-CoA synthetase short chain family member 2.	0.886
ACLY	FASN	ENSCAFP00000023291	ENSCAFP00000009039	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fatty acid synthase.	0.995
ACLY	LOC100856570	ENSCAFP00000023291	ENSCAFP00000013625	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.557
ACLY	LOC487740	ENSCAFP00000023291	ENSCAFP00000036914	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.557
ACSS2	ACACB	ENSCAFP00000065471	ENSCAFP00000016357	Acyl-CoA synthetase short chain family member 2.	Acetyl-CoA carboxylase beta.	0.918
ACSS2	ACLY	ENSCAFP00000065471	ENSCAFP00000023291	Acyl-CoA synthetase short chain family member 2.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.886
ACSS2	FASN	ENSCAFP00000065471	ENSCAFP00000009039	Acyl-CoA synthetase short chain family member 2.	Fatty acid synthase.	0.675
FASN	ACACB	ENSCAFP00000009039	ENSCAFP00000016357	Fatty acid synthase.	Acetyl-CoA carboxylase beta.	0.942
FASN	ACLY	ENSCAFP00000009039	ENSCAFP00000023291	Fatty acid synthase.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.995