NPPC protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NPPC

Natriuretic peptide C. (126 aa)

Predicted Functional Partners:

NPR2

0.999

NPR3

0.990

NPR1

0.956

NPPA

0.944

F1P7U7_CANLF

0.698

GUCY2F

0.692

GUCY2C

0.688

PDE3A

0.664

PDYN

0.601

PLPP4

0.597

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F1P7U7_CANLF	GUCY2F	ENSCAFP00000007834	ENSCAFP00000026657	Guanylate cyclase.	Guanylate cyclase.	0.506
F1P7U7_CANLF	NPPA	ENSCAFP00000007834	ENSCAFP00000053231	Guanylate cyclase.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.859
F1P7U7_CANLF	NPPC	ENSCAFP00000007834	ENSCAFP00000016394	Guanylate cyclase.	Natriuretic peptide C.	0.698
F1P7U7_CANLF	PDE3A	ENSCAFP00000007834	ENSCAFP00000018259	Guanylate cyclase.	Phosphodiesterase.	0.639
GUCY2C	NPPA	ENSCAFP00000019240	ENSCAFP00000053231	Guanylate cyclase.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.840
GUCY2C	NPPC	ENSCAFP00000019240	ENSCAFP00000016394	Guanylate cyclase.	Natriuretic peptide C.	0.688
GUCY2C	NPR3	ENSCAFP00000019240	ENSCAFP00000027839	Guanylate cyclase.	Natriuretic peptide receptor 3.	0.481
GUCY2C	PDE3A	ENSCAFP00000019240	ENSCAFP00000018259	Guanylate cyclase.	Phosphodiesterase.	0.835
GUCY2F	F1P7U7_CANLF	ENSCAFP00000026657	ENSCAFP00000007834	Guanylate cyclase.	Guanylate cyclase.	0.506
GUCY2F	NPPA	ENSCAFP00000026657	ENSCAFP00000053231	Guanylate cyclase.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.857
GUCY2F	NPPC	ENSCAFP00000026657	ENSCAFP00000016394	Guanylate cyclase.	Natriuretic peptide C.	0.692
GUCY2F	PDE3A	ENSCAFP00000026657	ENSCAFP00000018259	Guanylate cyclase.	Phosphodiesterase.	0.639
NPPA	F1P7U7_CANLF	ENSCAFP00000053231	ENSCAFP00000007834	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Guanylate cyclase.	0.859
NPPA	GUCY2C	ENSCAFP00000053231	ENSCAFP00000019240	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Guanylate cyclase.	0.840
NPPA	GUCY2F	ENSCAFP00000053231	ENSCAFP00000026657	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Guanylate cyclase.	0.857
NPPA	NPPC	ENSCAFP00000053231	ENSCAFP00000016394	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Natriuretic peptide C.	0.944
NPPA	NPR1	ENSCAFP00000053231	ENSCAFP00000025806	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Guanylate cyclase.	0.998
NPPA	NPR2	ENSCAFP00000053231	ENSCAFP00000052054	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Guanylate cyclase.	0.995
NPPA	NPR3	ENSCAFP00000053231	ENSCAFP00000027839	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	Natriuretic peptide receptor 3.	0.993
NPPC	F1P7U7_CANLF	ENSCAFP00000016394	ENSCAFP00000007834	Natriuretic peptide C.	Guanylate cyclase.	0.698