PRKX protein (Canis lupus familiaris) - STRING interaction network

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Score

PRKX

Protein kinase X-linked. (342 aa)

Predicted Functional Partners:

PRKAR2A

0.986

PRKAR1B

0.979

PRKAR2B

0.970

AKAP14

0.948

PRKACB

0.905

PRKACA

0.905

PRKAR1A

0.894

ENSCAFP00000054742

0.859

SMO

0.847

LOC484191

0.834

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP14	PRKACA	ENSCAFP00000066608	ENSCAFP00000053880	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.970
AKAP14	PRKACB	ENSCAFP00000066608	ENSCAFP00000030135	Uncharacterized protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.970
AKAP14	PRKAR1A	ENSCAFP00000066608	ENSCAFP00000047963	Uncharacterized protein.	Protein kinase cAMP-dependent type I regulatory subunit alpha.	0.718
AKAP14	PRKAR1B	ENSCAFP00000066608	ENSCAFP00000016544	Uncharacterized protein.	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.955
AKAP14	PRKAR2A	ENSCAFP00000066608	ENSCAFP00000017854	Uncharacterized protein.	Protein kinase cAMP-dependent type II regulatory subunit alpha.	0.955
AKAP14	PRKAR2B	ENSCAFP00000066608	ENSCAFP00000060895	Uncharacterized protein.	Protein kinase cAMP-dependent type II regulatory subunit beta.	0.955
AKAP14	PRKX	ENSCAFP00000066608	ENSCAFP00000016461	Uncharacterized protein.	Protein kinase X-linked.	0.948
ENSCAFP00000054742	PRKACA	ENSCAFP00000054742	ENSCAFP00000053880	DUF1908 domain-containing protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.884
ENSCAFP00000054742	PRKACB	ENSCAFP00000054742	ENSCAFP00000030135	DUF1908 domain-containing protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.866
ENSCAFP00000054742	PRKX	ENSCAFP00000054742	ENSCAFP00000016461	DUF1908 domain-containing protein.	Protein kinase X-linked.	0.859
LOC484191	PRKACA	ENSCAFP00000003155	ENSCAFP00000053880	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.849
LOC484191	PRKACB	ENSCAFP00000003155	ENSCAFP00000030135	Uncharacterized protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.829
LOC484191	PRKX	ENSCAFP00000003155	ENSCAFP00000016461	Uncharacterized protein.	Protein kinase X-linked.	0.834
PRKACA	AKAP14	ENSCAFP00000053880	ENSCAFP00000066608	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Uncharacterized protein.	0.970
PRKACA	ENSCAFP00000054742	ENSCAFP00000053880	ENSCAFP00000054742	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	DUF1908 domain-containing protein.	0.884
PRKACA	LOC484191	ENSCAFP00000053880	ENSCAFP00000003155	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Uncharacterized protein.	0.849
PRKACA	PRKACB	ENSCAFP00000053880	ENSCAFP00000030135	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.987
PRKACA	PRKAR1A	ENSCAFP00000053880	ENSCAFP00000047963	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Protein kinase cAMP-dependent type I regulatory subunit alpha.	0.987
PRKACA	PRKAR1B	ENSCAFP00000053880	ENSCAFP00000016544	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.999
PRKACA	PRKAR2A	ENSCAFP00000053880	ENSCAFP00000017854	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Protein kinase cAMP-dependent type II regulatory subunit alpha.	0.995