NR5A2 protein (Canis lupus familiaris) - STRING interaction network

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Score

NR5A2

Nuclear receptor subfamily 5 group A member 2. (519 aa)

Predicted Functional Partners:

NCOA3

0.875

ZNF217

0.806

NR0B2

0.770

CTNNB1

0.728

NR0B1

0.725

PPARGC1A

0.700

SYNGR2

0.642

NCOA2

0.620

HOXB7

0.613

ESR1

0.596

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	ESR1	ENSCAFP00000007783	ENSCAFP00000000624	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.742
CTNNB1	NR5A2	ENSCAFP00000007783	ENSCAFP00000016464	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Nuclear receptor subfamily 5 group A member 2.	0.728
ESR1	CTNNB1	ENSCAFP00000000624	ENSCAFP00000007783	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.742
ESR1	NCOA2	ENSCAFP00000000624	ENSCAFP00000065782	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator 2.	0.993
ESR1	NCOA3	ENSCAFP00000000624	ENSCAFP00000015958	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.984
ESR1	NR5A2	ENSCAFP00000000624	ENSCAFP00000016464	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor subfamily 5 group A member 2.	0.596
ESR1	PPARGC1A	ENSCAFP00000000624	ENSCAFP00000050517	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	PPARG coactivator 1 alpha.	0.674
ESR1	ZNF217	ENSCAFP00000000624	ENSCAFP00000040038	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Zinc finger protein 217.	0.617
HOXB7	NR5A2	ENSCAFP00000024794	ENSCAFP00000016464	Homeobox B7.	Nuclear receptor subfamily 5 group A member 2.	0.613
NCOA2	ESR1	ENSCAFP00000065782	ENSCAFP00000000624	Nuclear receptor coactivator 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.993
NCOA2	NCOA3	ENSCAFP00000065782	ENSCAFP00000015958	Nuclear receptor coactivator 2.	Nuclear receptor coactivator.	0.571
NCOA2	NR0B2	ENSCAFP00000065782	ENSCAFP00000018058	Nuclear receptor coactivator 2.	Nuclear receptor subfamily 0 group B member 2.	0.454
NCOA2	NR5A2	ENSCAFP00000065782	ENSCAFP00000016464	Nuclear receptor coactivator 2.	Nuclear receptor subfamily 5 group A member 2.	0.620
NCOA2	PPARGC1A	ENSCAFP00000065782	ENSCAFP00000050517	Nuclear receptor coactivator 2.	PPARG coactivator 1 alpha.	0.431
NCOA3	ESR1	ENSCAFP00000015958	ENSCAFP00000000624	Nuclear receptor coactivator.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.984
NCOA3	NCOA2	ENSCAFP00000015958	ENSCAFP00000065782	Nuclear receptor coactivator.	Nuclear receptor coactivator 2.	0.571
NCOA3	NR5A2	ENSCAFP00000015958	ENSCAFP00000016464	Nuclear receptor coactivator.	Nuclear receptor subfamily 5 group A member 2.	0.875
NCOA3	ZNF217	ENSCAFP00000015958	ENSCAFP00000040038	Nuclear receptor coactivator.	Zinc finger protein 217.	0.836
NR0B1	NR5A2	ENSCAFP00000050188	ENSCAFP00000016464	Nuclear receptor subfamily 0 group B member 1.	Nuclear receptor subfamily 5 group A member 2.	0.725
NR0B2	NCOA2	ENSCAFP00000018058	ENSCAFP00000065782	Nuclear receptor subfamily 0 group B member 2.	Nuclear receptor coactivator 2.	0.454