STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TBRG1Transforming growth factor beta regulator 1. (411 aa)    
Predicted Functional Partners:
COPS2
COP9 signalosome subunit 2.
   
  
 0.716
NEK8
NIMA related kinase 8.
   
  
 0.703
SLC29A2
Solute carrier family 29 member 2.
      
 0.692
KNTC1
Kinetochore associated 1.
      
 0.683
L3MBTL2
L3MBTL histone methyl-lysine binding protein 2.
   
  
 0.677
FBXO3
F-box protein 3.
      
 0.676
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
    
 0.640
CACNG7
Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
  
 0.639
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.625
GDPD5
Glycerophosphodiester phosphodiesterase domain containing 5.
      
 0.615
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.