STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Experiments
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[Homology]
Score
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (443 aa)    
Predicted Functional Partners:
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]
 
 
 0.999
PRKACB
Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.
 
 
 0.993
PRKX
Protein kinase X-linked.
 
 
 0.979
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
  
  
0.978
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
  
  
0.977
AKAP14
Uncharacterized protein.
    
  0.955
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
  
  
 
0.834
LIPE
Lipase E, hormone sensitive type.
     
 0.778
SGK2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
 
  
 
 0.767
MARK1
Non-specific serine/threonine protein kinase.
      
 0.693
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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