node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSG | AMBP | ENSCAFP00000019983 | ENSCAFP00000004896 | Alpha 2-HS glycoprotein. | Alpha-1-microglobulin/bikunin precursor. | 0.892 |
AHSG | APOA1 | ENSCAFP00000019983 | ENSCAFP00000019630 | Alpha 2-HS glycoprotein. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.808 |
AHSG | APOA2 | ENSCAFP00000019983 | ENSCAFP00000018988 | Alpha 2-HS glycoprotein. | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | 0.878 |
AHSG | APOC3 | ENSCAFP00000019983 | ENSCAFP00000019635 | Alpha 2-HS glycoprotein. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.796 |
AHSG | APOH | ENSCAFP00000019983 | ENSCAFP00000016597 | Alpha 2-HS glycoprotein. | Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. | 0.937 |
AHSG | F2 | ENSCAFP00000019983 | ENSCAFP00000037638 | Alpha 2-HS glycoprotein. | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | 0.928 |
AHSG | FGG | ENSCAFP00000019983 | ENSCAFP00000012417 | Alpha 2-HS glycoprotein. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.898 |
AHSG | PLG | ENSCAFP00000019983 | ENSCAFP00000001078 | Alpha 2-HS glycoprotein. | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.929 |
AHSG | SERPINC1 | ENSCAFP00000019983 | ENSCAFP00000021382 | Alpha 2-HS glycoprotein. | Serpin family C member 1; Belongs to the serpin family. | 0.824 |
AMBP | AHSG | ENSCAFP00000004896 | ENSCAFP00000019983 | Alpha-1-microglobulin/bikunin precursor. | Alpha 2-HS glycoprotein. | 0.892 |
AMBP | APOA1 | ENSCAFP00000004896 | ENSCAFP00000019630 | Alpha-1-microglobulin/bikunin precursor. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.661 |
AMBP | APOA2 | ENSCAFP00000004896 | ENSCAFP00000018988 | Alpha-1-microglobulin/bikunin precursor. | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | 0.821 |
AMBP | APOC3 | ENSCAFP00000004896 | ENSCAFP00000019635 | Alpha-1-microglobulin/bikunin precursor. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.711 |
AMBP | APOH | ENSCAFP00000004896 | ENSCAFP00000016597 | Alpha-1-microglobulin/bikunin precursor. | Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. | 0.869 |
AMBP | F2 | ENSCAFP00000004896 | ENSCAFP00000037638 | Alpha-1-microglobulin/bikunin precursor. | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | 0.900 |
AMBP | FGG | ENSCAFP00000004896 | ENSCAFP00000012417 | Alpha-1-microglobulin/bikunin precursor. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.840 |
AMBP | PLG | ENSCAFP00000004896 | ENSCAFP00000001078 | Alpha-1-microglobulin/bikunin precursor. | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.872 |
AMBP | SERPINC1 | ENSCAFP00000004896 | ENSCAFP00000021382 | Alpha-1-microglobulin/bikunin precursor. | Serpin family C member 1; Belongs to the serpin family. | 0.890 |
APOA1 | AHSG | ENSCAFP00000019630 | ENSCAFP00000019983 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Alpha 2-HS glycoprotein. | 0.808 |
APOA1 | AMBP | ENSCAFP00000019630 | ENSCAFP00000004896 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Alpha-1-microglobulin/bikunin precursor. | 0.661 |