TXNIP protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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[Homology]

Score

TXNIP

Thioredoxin interacting protein. (391 aa)

Predicted Functional Partners:

J9NWJ5_CANLF

0.997

LOC474798

0.989

TXN2

0.979

NLRP3

0.917

ITCH

0.911

VAV2

0.840

ENSCAFP00000056985

0.810

PTPN11

0.728

CASP4

0.728

LOC100683481

0.728

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP4	J9NWJ5_CANLF	ENSCAFP00000031566	ENSCAFP00000037540	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Thioredoxin; Belongs to the thioredoxin family.	0.405
CASP4	NLRP3	ENSCAFP00000031566	ENSCAFP00000015730	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 3.	0.757
CASP4	TXNIP	ENSCAFP00000031566	ENSCAFP00000016786	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Thioredoxin interacting protein.	0.728
ENSCAFP00000056985	TXN2	ENSCAFP00000056985	ENSCAFP00000002247	Thioredoxin domain-containing protein.	Thioredoxin 2.	0.515
ENSCAFP00000056985	TXNIP	ENSCAFP00000056985	ENSCAFP00000016786	Thioredoxin domain-containing protein.	Thioredoxin interacting protein.	0.810
ITCH	TXNIP	ENSCAFP00000011172	ENSCAFP00000016786	E3 ubiquitin-protein ligase.	Thioredoxin interacting protein.	0.911
J9NWJ5_CANLF	CASP4	ENSCAFP00000037540	ENSCAFP00000031566	Thioredoxin; Belongs to the thioredoxin family.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.405
J9NWJ5_CANLF	TXN2	ENSCAFP00000037540	ENSCAFP00000002247	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin 2.	0.581
J9NWJ5_CANLF	TXNIP	ENSCAFP00000037540	ENSCAFP00000016786	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin interacting protein.	0.997
LOC100683481	TXNIP	ENSCAFP00000045355	ENSCAFP00000016786	Tyrosine-protein phosphatase domain-containing protein.	Thioredoxin interacting protein.	0.728
LOC474798	TXN2	ENSCAFP00000045366	ENSCAFP00000002247	Thioredoxin domain-containing protein.	Thioredoxin 2.	0.958
LOC474798	TXNIP	ENSCAFP00000045366	ENSCAFP00000016786	Thioredoxin domain-containing protein.	Thioredoxin interacting protein.	0.989
NLRP3	CASP4	ENSCAFP00000015730	ENSCAFP00000031566	NLR family pyrin domain containing 3.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.757
NLRP3	TXNIP	ENSCAFP00000015730	ENSCAFP00000016786	NLR family pyrin domain containing 3.	Thioredoxin interacting protein.	0.917
PTPN11	TXNIP	ENSCAFP00000013074	ENSCAFP00000016786	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Thioredoxin interacting protein.	0.728
TXN2	ENSCAFP00000056985	ENSCAFP00000002247	ENSCAFP00000056985	Thioredoxin 2.	Thioredoxin domain-containing protein.	0.515
TXN2	J9NWJ5_CANLF	ENSCAFP00000002247	ENSCAFP00000037540	Thioredoxin 2.	Thioredoxin; Belongs to the thioredoxin family.	0.581
TXN2	LOC474798	ENSCAFP00000002247	ENSCAFP00000045366	Thioredoxin 2.	Thioredoxin domain-containing protein.	0.958
TXN2	TXNIP	ENSCAFP00000002247	ENSCAFP00000016786	Thioredoxin 2.	Thioredoxin interacting protein.	0.979
TXNIP	CASP4	ENSCAFP00000016786	ENSCAFP00000031566	Thioredoxin interacting protein.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.728