STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HELZHelicase with zinc finger. (1945 aa)    
Predicted Functional Partners:
PITPNC1
Phosphatidylinositol transfer protein cytoplasmic 1.
   
  
 0.870
KMT2E
Lysine methyltransferase 2E.
   
  
 0.821
CNOT1
CCR4-NOT transcription complex subunit 1.
   
 
 0.815
RC3H2
Ring finger and CCCH-type domains 2.
   
 
 0.788
OPTC
Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
      
 0.762
ATXN2L
Ataxin 2 like.
   
 
 0.735
CSTF2T
RRM domain-containing protein.
    
 
 0.724
MAP3K2
Mitogen-activated protein kinase kinase kinase 2.
   
 
 0.721
SMYD3
SET and MYND domain containing 3.
    
 
 0.712
PKN1
Protein kinase N1.
   
  
 0.693
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.