SNAI1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SNAI1

Snail family transcriptional repressor 1. (263 aa)

Predicted Functional Partners:

KPNB1

0.812

KDM1A

0.805

CDH1

0.784

ZEB1

0.751

SMAD4

0.751

SMAD3

0.750

TWIST2

0.744

RCOR1

0.723

BTRC

0.719

GSK3B

0.708

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	GSK3B	ENSCAFP00000014526	ENSCAFP00000034412	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.767
BTRC	SMAD4	ENSCAFP00000014526	ENSCAFP00000052646	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Mothers against decapentaplegic homolog.	0.640
BTRC	SNAI1	ENSCAFP00000014526	ENSCAFP00000016886	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Snail family transcriptional repressor 1.	0.719
CDH1	GSK3B	ENSCAFP00000030112	ENSCAFP00000034412	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.675
CDH1	SMAD3	ENSCAFP00000030112	ENSCAFP00000025647	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Mothers against decapentaplegic homolog.	0.686
CDH1	SMAD4	ENSCAFP00000030112	ENSCAFP00000052646	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Mothers against decapentaplegic homolog.	0.652
CDH1	SNAI1	ENSCAFP00000030112	ENSCAFP00000016886	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Snail family transcriptional repressor 1.	0.784
CDH1	TWIST2	ENSCAFP00000030112	ENSCAFP00000018365	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Twist family bHLH transcription factor 2.	0.596
CDH1	ZEB1	ENSCAFP00000030112	ENSCAFP00000043378	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Zinc finger E-box binding homeobox 1.	0.882
GSK3B	BTRC	ENSCAFP00000034412	ENSCAFP00000014526	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.767
GSK3B	CDH1	ENSCAFP00000034412	ENSCAFP00000030112	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	0.675
GSK3B	SMAD3	ENSCAFP00000034412	ENSCAFP00000025647	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.597
GSK3B	SMAD4	ENSCAFP00000034412	ENSCAFP00000052646	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.497
GSK3B	SNAI1	ENSCAFP00000034412	ENSCAFP00000016886	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Snail family transcriptional repressor 1.	0.708
GSK3B	ZEB1	ENSCAFP00000034412	ENSCAFP00000043378	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Zinc finger E-box binding homeobox 1.	0.556
KDM1A	RCOR1	ENSCAFP00000053375	ENSCAFP00000026701	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	REST corepressor 1.	0.998
KDM1A	SNAI1	ENSCAFP00000053375	ENSCAFP00000016886	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Snail family transcriptional repressor 1.	0.805
KPNB1	SNAI1	ENSCAFP00000044873	ENSCAFP00000016886	Karyopherin subunit beta 1.	Snail family transcriptional repressor 1.	0.812
RCOR1	KDM1A	ENSCAFP00000026701	ENSCAFP00000053375	REST corepressor 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.998
RCOR1	SNAI1	ENSCAFP00000026701	ENSCAFP00000016886	REST corepressor 1.	Snail family transcriptional repressor 1.	0.723