STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1DET1 partner of COP1 E3 ubiquitin ligase. (572 aa)    
Predicted Functional Partners:
COP1
COP1 E3 ubiquitin ligase.
   
 0.981
DDB1
Damage specific DNA binding protein 1.
   
 
 0.928
CUL4B
Cullin 4B; Belongs to the cullin family.
    
 
 0.838
CUL4A
Cullin 4A; Belongs to the cullin family.
   
 
 0.832
ATXN7L3
Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]
   
  
 0.703
DDA1
DET1 and DDB1 associated 1.
   
 
 0.664
TRIB1
Protein kinase domain-containing protein.
    
 
 0.632
STK40
Serine/threonine kinase 40.
    
 
 0.597
ETV1
ETS variant 1.
    
 
 0.590
ETV5
ETS variant 5.
    
 
 0.533
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.