STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCCSCytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (259 aa)    
Predicted Functional Partners:
COX10
Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10.
   
 
 0.967
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
     
 0.932
HMOX2
Heme oxygenase 2.
     
 0.928
HMOX1
Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.
     
  0.900
COX15
Cytochrome c oxidase assembly homolog COX15.
 
 
 
 0.882
ARHGAP6
Rho GTPase activating protein 6.
      
 0.767
MRPL35
Mitochondrial ribosomal protein L35.
   
  
 0.734
PMPCB
Peptidase, mitochondrial processing beta subunit; Belongs to the peptidase M16 family.
   
  
 0.711
B3GLCT
Beta 3-glucosyltransferase.
   
  
 0.704
FBXL15
F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family.
      
 0.700
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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