USP4 protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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USP4

Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (964 aa)

Predicted Functional Partners:

SART3

0.965

TRAF6

0.849

TOX4

0.824

GIGYF2

0.808

TBC1D25

0.790

RBMX2

0.785

UBB

0.774

OTUD6B

0.771

IDE

0.748

TRAF2

0.739

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GIGYF2	RBMX2	ENSCAFP00000016998	ENSCAFP00000027683	GRB10 interacting GYF protein 2.	RNA binding motif protein X-linked 2.	0.874
GIGYF2	TOX4	ENSCAFP00000016998	ENSCAFP00000008430	GRB10 interacting GYF protein 2.	TOX high mobility group box family member 4.	0.879
GIGYF2	USP4	ENSCAFP00000016998	ENSCAFP00000017081	GRB10 interacting GYF protein 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.808
IDE	UBB	ENSCAFP00000011097	ENSCAFP00000063279	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Ubiquitin B.	0.561
IDE	USP4	ENSCAFP00000011097	ENSCAFP00000017081	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.748
OTUD6B	USP4	ENSCAFP00000037443	ENSCAFP00000017081	OTU domain containing 6B.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.771
RBMX2	GIGYF2	ENSCAFP00000027683	ENSCAFP00000016998	RNA binding motif protein X-linked 2.	GRB10 interacting GYF protein 2.	0.874
RBMX2	TOX4	ENSCAFP00000027683	ENSCAFP00000008430	RNA binding motif protein X-linked 2.	TOX high mobility group box family member 4.	0.873
RBMX2	USP4	ENSCAFP00000027683	ENSCAFP00000017081	RNA binding motif protein X-linked 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.785
SART3	UBB	ENSCAFP00000057845	ENSCAFP00000063279	Spliceosome associated factor 3, U4/U6 recycling protein.	Ubiquitin B.	0.428
SART3	USP4	ENSCAFP00000057845	ENSCAFP00000017081	Spliceosome associated factor 3, U4/U6 recycling protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.965
TBC1D25	TRAF6	ENSCAFP00000022790	ENSCAFP00000010159	TBC1 domain family member 25.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.468
TBC1D25	USP4	ENSCAFP00000022790	ENSCAFP00000017081	TBC1 domain family member 25.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.790
TOX4	GIGYF2	ENSCAFP00000008430	ENSCAFP00000016998	TOX high mobility group box family member 4.	GRB10 interacting GYF protein 2.	0.879
TOX4	RBMX2	ENSCAFP00000008430	ENSCAFP00000027683	TOX high mobility group box family member 4.	RNA binding motif protein X-linked 2.	0.873
TOX4	USP4	ENSCAFP00000008430	ENSCAFP00000017081	TOX high mobility group box family member 4.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.824
TRAF2	TRAF6	ENSCAFP00000028895	ENSCAFP00000010159	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.961
TRAF2	UBB	ENSCAFP00000028895	ENSCAFP00000063279	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin B.	0.644
TRAF2	USP4	ENSCAFP00000028895	ENSCAFP00000017081	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.739
TRAF6	TBC1D25	ENSCAFP00000010159	ENSCAFP00000022790	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TBC1 domain family member 25.	0.468

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.861

expected number of edges:

13

PPI enrichment p-value:

0.00999

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070925

Organelle assembly

6 of 126

2.03

3.43

2.58e-08

GO:0051231

Spindle elongation

3 of 3

3.35

8.90e-07

GO:0090307

Mitotic spindle assembly

3 of 10

2.83

2.87

5.25e-06

GO:0007018

Microtubule-based movement

5 of 157

1.85

2.52

2.00e-06

GO:0022607

Cellular component assembly

7 of 390

1.6

2.47

1.13e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003777

Microtubule motor activity

5 of 101

2.04

2.87

8.42e-07

GO:0008017

Microtubule binding

5 of 126

1.95

2.75

9.70e-07

GO:0140657

ATP-dependent activity

6 of 597

1.35

1.55

2.02e-05

GO:0005515

Protein binding

6 of 1282

1.02

0.84

0.0015

GO:0035639

Purine ribonucleoside triphosphate binding

6 of 1740

0.89

0.62

0.0074

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015630

Microtubule cytoskeleton

9 of 291

1.84

4.43

1.90e-13

GO:0005874

Microtubule

6 of 131

2.01

3.75

2.67e-09

GO:0005815

Microtubule organizing center

4 of 91

1.99

2.53

4.47e-06

GO:0005929

Cilium

3 of 96

1.84

1.59

0.00052

GO:0036064

Ciliary basal body

2 of 28

2.2

1.3

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4249

Mixed, incl. Small GTPase superfamily, ARF type, and Spindle pole body-associated protein Vik1/Cik1, microtubule binding domain

5 of 12

2.97

5.41

9.02e-11

CL:4252

Mixed, incl. Ciliary membrane, and Long-chain fatty acid metabolic process

4 of 5

3.25

5.02

7.03e-10

CL:4227

Mixed, incl. Kelch, and Kinesin motor domain, conserved site

6 of 51

2.42

4.98

9.02e-11

CL:4549

Kinesin motor domain, and Microtubule minus-end

4 of 27

2.52

3.62

1.15e-07

CL:4554

Mixed, incl. Chromosome passenger complex, and POLO box domain

2 of 6

2.87

1.77

0.00060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

4 of 63

2.15

2.43

1.41e-05

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

4 of 87

2.01

2.24

2.45e-05

MAP-8856688

Golgi-to-ER retrograde transport

4 of 96

1.97

2.21

2.45e-05

MAP-983231

Factors involved in megakaryocyte development and platelet production

4 of 99

1.96

2.2

2.45e-05

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

4 of 130

1.84

2.0

4.66e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034464

BBSome

3 of 3

3.35

3.3

1.08e-06

GOCC:0015630

Microtubule cytoskeleton

5 of 202

1.74

2.2

7.26e-06

GOCC:0043226

Organelle

9 of 5058

0.6

0.45

0.0037

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0493

Microtubule

5 of 61

2.26

3.87

1.22e-08

KW-0505

Motor protein

5 of 85

2.12

3.54

2.98e-08

KW-0547

Nucleotide-binding

6 of 670

1.3

1.51

1.29e-05

KW-0067

ATP-binding

5 of 594

1.27

1.26

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001752

Kinesin motor domain

5 of 66

2.23

3.23

3.01e-07

IPR036961

Kinesin motor domain superfamily

5 of 81

2.14

3.1

4.02e-07

IPR019821

Kinesin motor domain, conserved site

4 of 44

2.31

2.71

5.29e-06

IPR047149

Kinesin-like protein KIF11-like

2 of 2

3.35

1.67

0.0010

IPR027640

Kinesin-like protein

3 of 61

2.04

1.38

0.0021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

4 of 61

2.17

2.63

5.36e-06

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