HSPA8 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJA1	DNAJA2	ENSCAFP00000002660	ENSCAFP00000032051	DnaJ heat shock protein family (Hsp40) member A1.	Uncharacterized protein.	0.660
DNAJA1	ENSCAFP00000061869	ENSCAFP00000002660	ENSCAFP00000061869	DnaJ heat shock protein family (Hsp40) member A1.	Uncharacterized protein.	0.421
DNAJA1	HSP90AA1	ENSCAFP00000002660	ENSCAFP00000026650	DnaJ heat shock protein family (Hsp40) member A1.	Heat shock protein 90 alpha family class A member 1.	0.534
DNAJA1	HSP90AB1	ENSCAFP00000002660	ENSCAFP00000002914	DnaJ heat shock protein family (Hsp40) member A1.	Heat shock protein 90 alpha family class B member 1.	0.803
DNAJA1	HSP90B1	ENSCAFP00000002660	ENSCAFP00000057899	DnaJ heat shock protein family (Hsp40) member A1.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.551
DNAJA1	HSPA4	ENSCAFP00000002660	ENSCAFP00000062263	DnaJ heat shock protein family (Hsp40) member A1.	Heat shock 70 kDa protein 4.	0.686
DNAJA1	HSPA8	ENSCAFP00000002660	ENSCAFP00000017166	DnaJ heat shock protein family (Hsp40) member A1.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.790
DNAJA1	HSPH1	ENSCAFP00000002660	ENSCAFP00000053951	DnaJ heat shock protein family (Hsp40) member A1.	Heat shock protein family H (Hsp110) member 1.	0.728
DNAJA2	DNAJA1	ENSCAFP00000032051	ENSCAFP00000002660	Uncharacterized protein.	DnaJ heat shock protein family (Hsp40) member A1.	0.660
DNAJA2	E2R7K1_CANLF	ENSCAFP00000032051	ENSCAFP00000031310	Uncharacterized protein.	J domain-containing protein.	0.660
DNAJA2	ENSCAFP00000061869	ENSCAFP00000032051	ENSCAFP00000061869	Uncharacterized protein.	Uncharacterized protein.	0.416
DNAJA2	HSP90AA1	ENSCAFP00000032051	ENSCAFP00000026650	Uncharacterized protein.	Heat shock protein 90 alpha family class A member 1.	0.416
DNAJA2	HSP90AB1	ENSCAFP00000032051	ENSCAFP00000002914	Uncharacterized protein.	Heat shock protein 90 alpha family class B member 1.	0.416
DNAJA2	HSP90B1	ENSCAFP00000032051	ENSCAFP00000057899	Uncharacterized protein.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.443
DNAJA2	HSPA4	ENSCAFP00000032051	ENSCAFP00000062263	Uncharacterized protein.	Heat shock 70 kDa protein 4.	0.567
DNAJA2	HSPA8	ENSCAFP00000032051	ENSCAFP00000017166	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.754
DNAJA2	HSPH1	ENSCAFP00000032051	ENSCAFP00000053951	Uncharacterized protein.	Heat shock protein family H (Hsp110) member 1.	0.567
DNAJB11	HSP90B1	ENSCAFP00000041977	ENSCAFP00000057899	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.935
DNAJB11	HSPA4	ENSCAFP00000041977	ENSCAFP00000062263	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Heat shock 70 kDa protein 4.	0.632
DNAJB11	HSPA8	ENSCAFP00000041977	ENSCAFP00000017166	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.780