STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIPA1L2Signal induced proliferation associated 1 like 2. (1720 aa)    
Predicted Functional Partners:
RAP1B
RAP1B, member of RAS oncogene family.
   
 0.921
RAP1A
RAP1A, member of RAS oncogene family.
   
 0.916
GNG4
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
      
 0.870
WDR27
WD repeat domain 27.
 
  
 
 0.787
LIMCH1
LIM and calponin homology domains 1.
   
  
 0.735
APPL1
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.
   
  
 0.722
RRP36
Ribosomal RNA processing 36.
      
 0.678
PRR35
Proline rich 35.
      
 0.678
CCDC36
Coiled-coil domain containing 36.
      
 0.677
DNAH7
Dynein axonemal heavy chain 7.
   
  
 0.666
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.