STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TPST2Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (377 aa)    
Predicted Functional Partners:
PDILT
Protein disulfide isomerase like, testis expressed.
    
 
 0.833
SLC35B2
Solute carrier family 35 member B2.
   
 
 0.798
PODXL2
Podocalyxin like 2.
    
  0.759
ADAM2
ADAM metallopeptidase domain 2.
      
 0.675
CHST8
Carbohydrate sulfotransferase.
   
  
 0.672
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.619
PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1.
  
 
 0.594
SLC2A6
Solute carrier family 2 member 6.
   
 
 0.588
SULT1A1
Sulfotransferase 1A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
      
 0.585
RTF1
RTF1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.573
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.