node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD5 | CIDEC | ENSCAFP00000043695 | ENSCAFP00000047599 | Abhydrolase domain containing 5. | Cell death inducing DFFA like effector c. | 0.525 |
ABHD5 | LIPE | ENSCAFP00000043695 | ENSCAFP00000007187 | Abhydrolase domain containing 5. | Lipase E, hormone sensitive type. | 0.619 |
ABHD5 | PLIN1 | ENSCAFP00000043695 | ENSCAFP00000017642 | Abhydrolase domain containing 5. | Perilipin; Belongs to the perilipin family. | 0.830 |
ABHD5 | PLIN4 | ENSCAFP00000043695 | ENSCAFP00000035972 | Abhydrolase domain containing 5. | Perilipin 4. | 0.414 |
CIDEC | ABHD5 | ENSCAFP00000047599 | ENSCAFP00000043695 | Cell death inducing DFFA like effector c. | Abhydrolase domain containing 5. | 0.525 |
CIDEC | LEP | ENSCAFP00000047599 | ENSCAFP00000002433 | Cell death inducing DFFA like effector c. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.591 |
CIDEC | LIPE | ENSCAFP00000047599 | ENSCAFP00000007187 | Cell death inducing DFFA like effector c. | Lipase E, hormone sensitive type. | 0.578 |
CIDEC | PLIN1 | ENSCAFP00000047599 | ENSCAFP00000017642 | Cell death inducing DFFA like effector c. | Perilipin; Belongs to the perilipin family. | 0.854 |
CIDEC | PLIN4 | ENSCAFP00000047599 | ENSCAFP00000035972 | Cell death inducing DFFA like effector c. | Perilipin 4. | 0.574 |
CIDEC | PPARG | ENSCAFP00000047599 | ENSCAFP00000007423 | Cell death inducing DFFA like effector c. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.545 |
LEP | CIDEC | ENSCAFP00000002433 | ENSCAFP00000047599 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Cell death inducing DFFA like effector c. | 0.591 |
LEP | LIPE | ENSCAFP00000002433 | ENSCAFP00000007187 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Lipase E, hormone sensitive type. | 0.712 |
LEP | PLIN1 | ENSCAFP00000002433 | ENSCAFP00000017642 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Perilipin; Belongs to the perilipin family. | 0.723 |
LEP | PPARG | ENSCAFP00000002433 | ENSCAFP00000007423 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.844 |
LEP | PRKACA | ENSCAFP00000002433 | ENSCAFP00000053880 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.569 |
LEP | PRKACB | ENSCAFP00000002433 | ENSCAFP00000030135 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.561 |
LIPE | ABHD5 | ENSCAFP00000007187 | ENSCAFP00000043695 | Lipase E, hormone sensitive type. | Abhydrolase domain containing 5. | 0.619 |
LIPE | CIDEC | ENSCAFP00000007187 | ENSCAFP00000047599 | Lipase E, hormone sensitive type. | Cell death inducing DFFA like effector c. | 0.578 |
LIPE | LEP | ENSCAFP00000007187 | ENSCAFP00000002433 | Lipase E, hormone sensitive type. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.712 |
LIPE | PLIN1 | ENSCAFP00000007187 | ENSCAFP00000017642 | Lipase E, hormone sensitive type. | Perilipin; Belongs to the perilipin family. | 0.921 |