RAE1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RAE1

SPO11 initiator of meiotic double stranded breaks. (396 aa)

Predicted Functional Partners:

MSH4

0.986

HORMAD1

0.958

REC114

0.941

MUS81

0.881

REC8

0.879

SYCE1

0.857

LOC102152531

0.855

LOC100687249

0.855

MND1

0.823

SYCP1

0.820

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HORMAD1	LOC100687249	ENSCAFP00000017772	ENSCAFP00000032258	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Cor1 domain-containing protein.	0.756
HORMAD1	LOC102152531	ENSCAFP00000017772	ENSCAFP00000031959	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Cor1 domain-containing protein.	0.756
HORMAD1	MND1	ENSCAFP00000017772	ENSCAFP00000062511	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Meiotic nuclear divisions 1.	0.612
HORMAD1	MSH4	ENSCAFP00000017772	ENSCAFP00000033551	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	MutS homolog 4.	0.639
HORMAD1	RAE1	ENSCAFP00000017772	ENSCAFP00000017710	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	SPO11 initiator of meiotic double stranded breaks.	0.958
HORMAD1	REC114	ENSCAFP00000017772	ENSCAFP00000026260	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	REC114 meiotic recombination protein.	0.735
HORMAD1	REC8	ENSCAFP00000017772	ENSCAFP00000017702	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	REC8 meiotic recombination protein.	0.874
HORMAD1	SYCE1	ENSCAFP00000017772	ENSCAFP00000033815	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Synaptonemal complex central element protein 1.	0.874
HORMAD1	SYCP1	ENSCAFP00000017772	ENSCAFP00000037843	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Synaptonemal complex protein 1.	0.922
LOC100687249	HORMAD1	ENSCAFP00000032258	ENSCAFP00000017772	Cor1 domain-containing protein.	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	0.756
LOC100687249	LOC102152531	ENSCAFP00000032258	ENSCAFP00000031959	Cor1 domain-containing protein.	Cor1 domain-containing protein.	0.901
LOC100687249	MSH4	ENSCAFP00000032258	ENSCAFP00000033551	Cor1 domain-containing protein.	MutS homolog 4.	0.682
LOC100687249	RAE1	ENSCAFP00000032258	ENSCAFP00000017710	Cor1 domain-containing protein.	SPO11 initiator of meiotic double stranded breaks.	0.855
LOC100687249	REC114	ENSCAFP00000032258	ENSCAFP00000026260	Cor1 domain-containing protein.	REC114 meiotic recombination protein.	0.670
LOC100687249	REC8	ENSCAFP00000032258	ENSCAFP00000017702	Cor1 domain-containing protein.	REC8 meiotic recombination protein.	0.704
LOC100687249	SYCE1	ENSCAFP00000032258	ENSCAFP00000033815	Cor1 domain-containing protein.	Synaptonemal complex central element protein 1.	0.785
LOC100687249	SYCP1	ENSCAFP00000032258	ENSCAFP00000037843	Cor1 domain-containing protein.	Synaptonemal complex protein 1.	0.681
LOC102152531	HORMAD1	ENSCAFP00000031959	ENSCAFP00000017772	Cor1 domain-containing protein.	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	0.756
LOC102152531	LOC100687249	ENSCAFP00000031959	ENSCAFP00000032258	Cor1 domain-containing protein.	Cor1 domain-containing protein.	0.901
LOC102152531	MSH4	ENSCAFP00000031959	ENSCAFP00000033551	Cor1 domain-containing protein.	MutS homolog 4.	0.682