STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (399 aa)    
Predicted Functional Partners:
PRKACB
Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.
 
 
 0.981
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]
 
 
 0.976
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
  
 
0.919
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
  
 
0.911
LIPE
Lipase E, hormone sensitive type.
   
 
 0.907
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
  
  
0.907
AKAP10
A-kinase anchoring protein 10.
   
 0.833
PRKX
Protein kinase X-linked.
 
 
 
 0.797
AKAP1
A-kinase anchoring protein 1.
   
 0.732
TSSK3
Testis specific serine kinase 3.
   
 
 0.697
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.