STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E2RBZ7_CANLFUncharacterized protein. (247 aa)    
Predicted Functional Partners:
HABP2
Hyaluronan binding protein 2.
   
 
 0.837
HGFAC
Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form; Belongs to the peptidase S1 family.
   
 
 0.837
F12
Coagulation factor XII.
   
 
 0.837
RHOBTB2
Rho related BTB domain containing 2.
   
 
 0.689
RIPK4
Receptor interacting serine/threonine kinase 4.
   
 
 0.632
RNASEL
Ribonuclease L.
   
 
 0.630
CTDNEP1
CTD nuclear envelope phosphatase 1.
    
 
 0.591
COL22A1
Collagen type XXII alpha 1 chain.
   
 
 0.582
MST1R
Macrophage stimulating 1 receptor.
   
 
 0.570
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 
 0.570
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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