BAG3 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

BAG3

BCL2 associated athanogene 3. (579 aa)

Predicted Functional Partners:

HSPB8

0.947

STUB1

0.917

HSPA1

0.898

HSPA8

0.849

HSPA1L

0.841

HSPA5

0.838

HSPA13

0.807

HSPH1

0.801

BCL2

0.796

HSPA4L

0.785

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG3	BCL2	ENSCAFP00000017970	ENSCAFP00000000102	BCL2 associated athanogene 3.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.796
BAG3	HSPA1	ENSCAFP00000017970	ENSCAFP00000000903	BCL2 associated athanogene 3.	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.898
BAG3	HSPA13	ENSCAFP00000017970	ENSCAFP00000036662	BCL2 associated athanogene 3.	Heat shock protein family A (Hsp70) member 13.	0.807
BAG3	HSPA1L	ENSCAFP00000017970	ENSCAFP00000000900	BCL2 associated athanogene 3.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.841
BAG3	HSPA4L	ENSCAFP00000017970	ENSCAFP00000005822	BCL2 associated athanogene 3.	Heat shock protein family A (Hsp70) member 4 like.	0.785
BAG3	HSPA5	ENSCAFP00000017970	ENSCAFP00000029957	BCL2 associated athanogene 3.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.838
BAG3	HSPA8	ENSCAFP00000017970	ENSCAFP00000017166	BCL2 associated athanogene 3.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.849
BAG3	HSPB8	ENSCAFP00000017970	ENSCAFP00000041782	BCL2 associated athanogene 3.	Heat shock protein beta-8; Displays temperature-dependent chaperone activity. Belongs to the small heat shock protein (HSP20) family.	0.947
BAG3	HSPH1	ENSCAFP00000017970	ENSCAFP00000053951	BCL2 associated athanogene 3.	Heat shock protein family H (Hsp110) member 1.	0.801
BAG3	STUB1	ENSCAFP00000017970	ENSCAFP00000036229	BCL2 associated athanogene 3.	STIP1 homology and U-box containing protein 1.	0.917
BCL2	BAG3	ENSCAFP00000000102	ENSCAFP00000017970	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	BCL2 associated athanogene 3.	0.796
BCL2	HSPA1	ENSCAFP00000000102	ENSCAFP00000000903	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.592
BCL2	HSPA5	ENSCAFP00000000102	ENSCAFP00000029957	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.615
HSPA1	BAG3	ENSCAFP00000000903	ENSCAFP00000017970	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	BCL2 associated athanogene 3.	0.898
HSPA1	BCL2	ENSCAFP00000000903	ENSCAFP00000000102	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.592
HSPA1	HSPA13	ENSCAFP00000000903	ENSCAFP00000036662	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	Heat shock protein family A (Hsp70) member 13.	0.552
HSPA1	HSPA1L	ENSCAFP00000000903	ENSCAFP00000000900	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.575
HSPA1	HSPA4L	ENSCAFP00000000903	ENSCAFP00000005822	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	Heat shock protein family A (Hsp70) member 4 like.	0.747
HSPA1	HSPA5	ENSCAFP00000000903	ENSCAFP00000029957	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.752
HSPA1	HSPA8	ENSCAFP00000000903	ENSCAFP00000017166	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.855