node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNOT8 | NR0B2 | ENSCAFP00000025982 | ENSCAFP00000018058 | CCR4-NOT transcription complex subunit 8. | Nuclear receptor subfamily 0 group B member 2. | 0.653 |
CNOT8 | SULT2B1 | ENSCAFP00000025982 | ENSCAFP00000005912 | CCR4-NOT transcription complex subunit 8. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.435 |
MED1 | NCOR2 | ENSCAFP00000024203 | ENSCAFP00000010374 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 2. | 0.729 |
MED1 | NR0B2 | ENSCAFP00000024203 | ENSCAFP00000018058 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 0 group B member 2. | 0.624 |
MED1 | NR1H4 | ENSCAFP00000024203 | ENSCAFP00000010196 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group H member 4. | 0.777 |
MED1 | NR5A2 | ENSCAFP00000024203 | ENSCAFP00000016464 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 5 group A member 2. | 0.520 |
MED1 | NR6A1 | ENSCAFP00000024203 | ENSCAFP00000029991 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 5 group A member 1. | 0.520 |
MED1 | PPARA | ENSCAFP00000024203 | ENSCAFP00000054067 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.858 |
MED1 | PPARG | ENSCAFP00000024203 | ENSCAFP00000007423 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.972 |
NCOR2 | MED1 | ENSCAFP00000010374 | ENSCAFP00000024203 | Nuclear receptor corepressor 2. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.729 |
NCOR2 | NR0B2 | ENSCAFP00000010374 | ENSCAFP00000018058 | Nuclear receptor corepressor 2. | Nuclear receptor subfamily 0 group B member 2. | 0.716 |
NCOR2 | NR1H4 | ENSCAFP00000010374 | ENSCAFP00000010196 | Nuclear receptor corepressor 2. | Nuclear receptor subfamily 1 group H member 4. | 0.803 |
NCOR2 | NR5A2 | ENSCAFP00000010374 | ENSCAFP00000016464 | Nuclear receptor corepressor 2. | Nuclear receptor subfamily 5 group A member 2. | 0.543 |
NCOR2 | NR6A1 | ENSCAFP00000010374 | ENSCAFP00000029991 | Nuclear receptor corepressor 2. | Nuclear receptor subfamily 5 group A member 1. | 0.543 |
NCOR2 | PPARA | ENSCAFP00000010374 | ENSCAFP00000054067 | Nuclear receptor corepressor 2. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.957 |
NCOR2 | PPARG | ENSCAFP00000010374 | ENSCAFP00000007423 | Nuclear receptor corepressor 2. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.974 |
NR0B2 | CNOT8 | ENSCAFP00000018058 | ENSCAFP00000025982 | Nuclear receptor subfamily 0 group B member 2. | CCR4-NOT transcription complex subunit 8. | 0.653 |
NR0B2 | MED1 | ENSCAFP00000018058 | ENSCAFP00000024203 | Nuclear receptor subfamily 0 group B member 2. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.624 |
NR0B2 | NCOR2 | ENSCAFP00000018058 | ENSCAFP00000010374 | Nuclear receptor subfamily 0 group B member 2. | Nuclear receptor corepressor 2. | 0.716 |
NR0B2 | NR1H4 | ENSCAFP00000018058 | ENSCAFP00000010196 | Nuclear receptor subfamily 0 group B member 2. | Nuclear receptor subfamily 1 group H member 4. | 0.631 |