node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | EGFR | ENSCAFP00000050335 | ENSCAFP00000005164 | CD44 antigen. | Receptor protein-tyrosine kinase. | 0.924 |
CD44 | IGF1 | ENSCAFP00000050335 | ENSCAFP00000058639 | CD44 antigen. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.557 |
CD44 | IGFBP3 | ENSCAFP00000050335 | ENSCAFP00000018107 | CD44 antigen. | Insulin like growth factor binding protein 3. | 0.714 |
CD44 | INS | ENSCAFP00000050335 | ENSCAFP00000051648 | CD44 antigen. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.659 |
CD44 | JAK2 | ENSCAFP00000050335 | ENSCAFP00000044346 | CD44 antigen. | Janus kinase 2. | 0.418 |
EGFR | CD44 | ENSCAFP00000005164 | ENSCAFP00000050335 | Receptor protein-tyrosine kinase. | CD44 antigen. | 0.924 |
EGFR | IGF1 | ENSCAFP00000005164 | ENSCAFP00000058639 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.961 |
EGFR | IGF1R | ENSCAFP00000005164 | ENSCAFP00000043796 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.676 |
EGFR | IGF2 | ENSCAFP00000005164 | ENSCAFP00000063478 | Receptor protein-tyrosine kinase. | Insulin like growth factor 2. | 0.803 |
EGFR | IGFBP3 | ENSCAFP00000005164 | ENSCAFP00000018107 | Receptor protein-tyrosine kinase. | Insulin like growth factor binding protein 3. | 0.597 |
EGFR | INS | ENSCAFP00000005164 | ENSCAFP00000051648 | Receptor protein-tyrosine kinase. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.959 |
EGFR | JAK2 | ENSCAFP00000005164 | ENSCAFP00000044346 | Receptor protein-tyrosine kinase. | Janus kinase 2. | 0.958 |
GHR | IGF1 | ENSCAFP00000057498 | ENSCAFP00000058639 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.864 |
GHR | IGF1R | ENSCAFP00000057498 | ENSCAFP00000043796 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Tyrosine-protein kinase receptor. | 0.562 |
GHR | IGF2 | ENSCAFP00000057498 | ENSCAFP00000063478 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Insulin like growth factor 2. | 0.525 |
GHR | IGFALS | ENSCAFP00000057498 | ENSCAFP00000028824 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Insulin like growth factor binding protein acid labile subunit. | 0.445 |
GHR | IGFBP3 | ENSCAFP00000057498 | ENSCAFP00000018107 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Insulin like growth factor binding protein 3. | 0.624 |
GHR | INS | ENSCAFP00000057498 | ENSCAFP00000051648 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.626 |
GHR | JAK2 | ENSCAFP00000057498 | ENSCAFP00000044346 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | Janus kinase 2. | 0.983 |
IGF1 | CD44 | ENSCAFP00000058639 | ENSCAFP00000050335 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | CD44 antigen. | 0.557 |