TMEM89 protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

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[Homology]

Score

TMEM89

Transmembrane protein 89. (159 aa)

Predicted Functional Partners:

LRRCC1

0.722

IQCF5

0.688

OAZ3

0.515

FSIP2

0.504

LOC611589

0.488

VDAC2

0.457

ENSCAFP00000052403

0.457

C17H1orf56

0.407

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C17H1orf56	LRRCC1	ENSCAFP00000031485	ENSCAFP00000012626	Chromosome 17 C1orf56 homolog.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.427
C17H1orf56	TMEM89	ENSCAFP00000031485	ENSCAFP00000018133	Chromosome 17 C1orf56 homolog.	Transmembrane protein 89.	0.407
ENSCAFP00000052403	LRRCC1	ENSCAFP00000052403	ENSCAFP00000012626	Uncharacterized protein.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.457
ENSCAFP00000052403	TMEM89	ENSCAFP00000052403	ENSCAFP00000018133	Uncharacterized protein.	Transmembrane protein 89.	0.457
FSIP2	IQCF5	ENSCAFP00000038019	ENSCAFP00000014809	Fibrous sheath interacting protein 2.	IQ motif containing F5.	0.471
FSIP2	LRRCC1	ENSCAFP00000038019	ENSCAFP00000012626	Fibrous sheath interacting protein 2.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.400
FSIP2	TMEM89	ENSCAFP00000038019	ENSCAFP00000018133	Fibrous sheath interacting protein 2.	Transmembrane protein 89.	0.504
IQCF5	FSIP2	ENSCAFP00000014809	ENSCAFP00000038019	IQ motif containing F5.	Fibrous sheath interacting protein 2.	0.471
IQCF5	LOC611589	ENSCAFP00000014809	ENSCAFP00000037382	IQ motif containing F5.	Uncharacterized protein.	0.470
IQCF5	LRRCC1	ENSCAFP00000014809	ENSCAFP00000012626	IQ motif containing F5.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.680
IQCF5	OAZ3	ENSCAFP00000014809	ENSCAFP00000018906	IQ motif containing F5.	Uncharacterized protein.	0.541
IQCF5	TMEM89	ENSCAFP00000014809	ENSCAFP00000018133	IQ motif containing F5.	Transmembrane protein 89.	0.688
LOC611589	IQCF5	ENSCAFP00000037382	ENSCAFP00000014809	Uncharacterized protein.	IQ motif containing F5.	0.470
LOC611589	LRRCC1	ENSCAFP00000037382	ENSCAFP00000012626	Uncharacterized protein.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.400
LOC611589	TMEM89	ENSCAFP00000037382	ENSCAFP00000018133	Uncharacterized protein.	Transmembrane protein 89.	0.488
LRRCC1	C17H1orf56	ENSCAFP00000012626	ENSCAFP00000031485	Leucine rich repeat and coiled-coil centrosomal protein 1.	Chromosome 17 C1orf56 homolog.	0.427
LRRCC1	ENSCAFP00000052403	ENSCAFP00000012626	ENSCAFP00000052403	Leucine rich repeat and coiled-coil centrosomal protein 1.	Uncharacterized protein.	0.457
LRRCC1	FSIP2	ENSCAFP00000012626	ENSCAFP00000038019	Leucine rich repeat and coiled-coil centrosomal protein 1.	Fibrous sheath interacting protein 2.	0.400
LRRCC1	IQCF5	ENSCAFP00000012626	ENSCAFP00000014809	Leucine rich repeat and coiled-coil centrosomal protein 1.	IQ motif containing F5.	0.680
LRRCC1	LOC611589	ENSCAFP00000012626	ENSCAFP00000037382	Leucine rich repeat and coiled-coil centrosomal protein 1.	Uncharacterized protein.	0.400

page 1 of 2

Network Stats

number of nodes:

6

number of edges:

11

average node degree:

3.67

avg. local clustering coefficient:

0.933

expected number of edges:

5

PPI enrichment p-value:

0.0153

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006635

Fatty acid beta-oxidation

8 of 50

2.38

6.45

1.96e-14

GO:0046395

Carboxylic acid catabolic process

9 of 182

1.87

4.54

2.34e-13

GO:0006631

Fatty acid metabolic process

9 of 257

1.72

3.74

3.62e-12

GO:0009437

Carnitine metabolic process

3 of 10

2.66

2.49

2.41e-05

GO:0019752

Carboxylic acid metabolic process

10 of 611

1.39

2.44

3.94e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016627

Oxidoreductase activity, acting on the CH-CH group of donors

5 of 56

2.13

2.99

6.81e-07

GO:0004095

Carnitine O-palmitoyltransferase activity

3 of 5

2.96

2.73

1.07e-05

GO:0003997

acyl-CoA oxidase activity

3 of 6

2.88

2.72

1.07e-05

GO:0050660

Flavin adenine dinucleotide binding

5 of 86

1.94

2.58

2.64e-06

GO:0003995

acyl-CoA dehydrogenase activity

3 of 11

2.61

2.47

2.60e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

8 of 1190

1.01

0.96

0.00013

GO:0031966

Mitochondrial membrane

5 of 494

1.18

0.83

0.0063

GO:0005743

Mitochondrial inner membrane

4 of 323

1.27

0.78

0.0144

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30918526

(2019) Maternal diet deficient in riboflavin induces embryonic death associated with alterations in the hepatic proteome of duck embryos.

6 of 27

2.53

5.04

1.27e-10

PMID:35073666

(2022) MicroRNA analysis reveals the role of miR-214 in duck adipocyte differentiation.

5 of 18

2.62

4.34

5.36e-09

PMID:28706492

(2017) Lower Expression of SLC27A1 Enhances Intramuscular Fat Deposition in Chicken via Down-Regulated Fatty Acid Oxidation Mediated by CPT1A.

4 of 14

2.64

3.26

7.72e-07

PMID:30365498

(2018) Proteome and microbiota analysis reveals alterations of liver-gut axis under different stocking density of Peking ducks.

4 of 22

2.44

2.95

2.26e-06

PMID:35950191

(2022) Integrated liver proteomics and metabolomics identify metabolic pathways affected by pantothenic acid deficiency in Pekin ducks.

5 of 62

2.09

2.93

7.72e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7416

Mixed, incl. Fatty acid beta-oxidation, and Fatty acid biosynthesis

9 of 91

2.17

6.25

1.43e-15

CL:7418

Fatty acid beta-oxidation, and CoA carboxylase activity

7 of 47

2.35

5.82

5.12e-13

CL:7426

Beta oxidation of hexanoyl-CoA to butanoyl-CoA, and acyl-CoA oxidase activity

5 of 12

2.8

5.26

1.24e-10

CL:7430

acyl-CoA oxidase activity, and long-chain-3-hydroxyacyl-CoA dehydrogenase activity

4 of 6

3.0

4.42

7.30e-09

CL:7500

Octanoyltransferase activity, and MaoC-like dehydratase domain

2 of 6

2.7

1.37

0.0032

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00071

Fatty acid degradation

7 of 24

2.64

7.39

2.06e-15

apla01212

Fatty acid metabolism

7 of 47

2.35

6.16

6.90e-14

apla03320

PPAR signaling pathway

5 of 49

2.19

3.87

7.53e-09

apla00410

beta-Alanine metabolism

3 of 21

2.33

2.47

1.80e-05

apla00640

Propanoate metabolism

3 of 23

2.29

2.45

1.84e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8978868

Fatty acid metabolism

9 of 183

1.87

4.51

2.72e-13

MAP-200425

Carnitine metabolism

4 of 16

2.58

3.46

2.78e-07

MAP-556833

Metabolism of lipids

9 of 787

1.24

1.71

5.33e-08

MAP-77289

Mitochondrial Fatty Acid Beta-Oxidation

3 of 35

2.11

1.66

0.00060

MAP-77286

Mitochondrial fatty acid beta-oxidation of saturated fatty acids

2 of 10

2.48

1.17

0.0073

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

8 of 742

1.21

1.45

3.73e-06

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 4962

0.48

0.32

0.0352

GOCC:0005737

Cytoplasm

10 of 5040

0.48

0.31

0.0352

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

4 of 49

2.09

2.47

9.41e-06

KW-0012

Acyltransferase

3 of 54

1.92

1.58

0.00065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02770

Acyl-CoA dehydrogenase, middle domain

5 of 13

2.76

4.85

7.25e-10

PF00755

Choline/Carnitine o-acyltransferase

3 of 7

2.81

2.51

2.51e-05

PF02771

Acyl-CoA dehydrogenase, N-terminal domain

3 of 10

2.66

2.38

3.98e-05

PF08028

Acyl-CoA dehydrogenase, C-terminal domain

3 of 11

2.61

2.37

3.98e-05

PF14749

Acyl-coenzyme A oxidase N-terminal

2 of 3

3.0

1.56

0.0015

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046373

Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

5 of 13

2.76

4.6

2.26e-09

IPR006091

Acyl-CoA oxidase/dehydrogenase, middle domain

5 of 13

2.76

4.6

2.26e-09

IPR036250

Acyl-CoA dehydrogenase-like, C-terminal

5 of 14

2.73

4.58

2.26e-09

IPR009100

Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily

5 of 14

2.73

4.58

2.26e-09

IPR037069

Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

4 of 12

2.7

3.55

2.28e-07

(more ...)

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