STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1656 aa)    
Predicted Functional Partners:
RAB5A
Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]
   
 0.928
C11H9orf72
Chromosome 11 C9orf72 homolog.
      
 0.900
SETX
Senataxin.
   
  
 0.743
NEK1
NIMA related kinase 1.
   
 
 0.732
RANBP2
RAN binding protein 2.
   
 
 0.730
TAF15
TATA-box binding protein associated factor 15.
   
 
 0.718
RABGEF1
RAB guanine nucleotide exchange factor 1.
   
 0.697
PFDN2
Prefoldin subunit 2.
   
  
 0.690
RIN3
Ras and Rab interactor 3.
   
 0.679
FUS
FUS RNA binding protein.
   
 
 0.669
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.