STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HTRA1HtrA serine peptidase 1. (403 aa)    
Predicted Functional Partners:
XIAP
Baculoviral IAP-repeat containing protein 4.
    
 
 0.608
F1PP29_CANLF
Uncharacterized protein.
    
   0.586
BIRC6
Baculoviral IAP repeat containing 6.
    
 
 0.582
TNFRSF1A
TNF receptor superfamily member 1A.
   
 
 0.564
DNAJC11
DnaJ heat shock protein family (Hsp40) member C11.
  
 
 0.548
SIL1
SIL1 nucleotide exchange factor.
   
 
 0.544
PSMD1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
    
 
 0.515
SPINK4
Serine peptidase inhibitor, Kazal type 4.
    
 
 0.508
CTSW
Cathepsin W; Belongs to the peptidase C1 family.
   
  
 0.503
COL22A1
Collagen type XXII alpha 1 chain.
    
 
 0.486
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.