ECE2 protein (Canis lupus familiaris) - STRING interaction network

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Score

ECE2

Endothelin converting enzyme 2. (765 aa)

Predicted Functional Partners:

EDN1

0.942

EEF1AKMT4

0.813

IDE

0.730

EDNRB

0.657

EDNRA

0.618

LOC100856208

0.543

ACE

0.536

APBA3

0.531

PLEKHG6

0.519

POLG2

0.501

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ECE2	ENSCAFP00000019153	ENSCAFP00000018518	Angiotensin-converting enzyme.	Endothelin converting enzyme 2.	0.536
ACE	EDN1	ENSCAFP00000019153	ENSCAFP00000014389	Angiotensin-converting enzyme.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.749
ACE	EDNRA	ENSCAFP00000019153	ENSCAFP00000011497	Angiotensin-converting enzyme.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.410
ACE	IDE	ENSCAFP00000019153	ENSCAFP00000011097	Angiotensin-converting enzyme.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.432
ACE	LOC100856208	ENSCAFP00000019153	ENSCAFP00000042858	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.903
APBA3	ECE2	ENSCAFP00000037390	ENSCAFP00000018518	Amyloid beta precursor protein binding family A member 3.	Endothelin converting enzyme 2.	0.531
ECE2	ACE	ENSCAFP00000018518	ENSCAFP00000019153	Endothelin converting enzyme 2.	Angiotensin-converting enzyme.	0.536
ECE2	APBA3	ENSCAFP00000018518	ENSCAFP00000037390	Endothelin converting enzyme 2.	Amyloid beta precursor protein binding family A member 3.	0.531
ECE2	EDN1	ENSCAFP00000018518	ENSCAFP00000014389	Endothelin converting enzyme 2.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.942
ECE2	EDNRA	ENSCAFP00000018518	ENSCAFP00000011497	Endothelin converting enzyme 2.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.618
ECE2	EDNRB	ENSCAFP00000018518	ENSCAFP00000007760	Endothelin converting enzyme 2.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.657
ECE2	EEF1AKMT4	ENSCAFP00000018518	ENSCAFP00000018453	Endothelin converting enzyme 2.	EEF1A lysine methyltransferase 4.	0.813
ECE2	IDE	ENSCAFP00000018518	ENSCAFP00000011097	Endothelin converting enzyme 2.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.730
ECE2	LOC100856208	ENSCAFP00000018518	ENSCAFP00000042858	Endothelin converting enzyme 2.	Angiotensin-converting enzyme.	0.543
ECE2	PLEKHG6	ENSCAFP00000018518	ENSCAFP00000035402	Endothelin converting enzyme 2.	Pleckstrin homology and RhoGEF domain containing G6.	0.519
ECE2	POLG2	ENSCAFP00000018518	ENSCAFP00000043187	Endothelin converting enzyme 2.	DNA polymerase gamma 2, accessory subunit.	0.501
EDN1	ACE	ENSCAFP00000014389	ENSCAFP00000019153	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Angiotensin-converting enzyme.	0.749
EDN1	ECE2	ENSCAFP00000014389	ENSCAFP00000018518	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin converting enzyme 2.	0.942
EDN1	EDNRA	ENSCAFP00000014389	ENSCAFP00000011497	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.999
EDN1	EDNRB	ENSCAFP00000014389	ENSCAFP00000007760	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.999