EXTL1 protein (Canis lupus familiaris) - STRING interaction network

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Score

EXTL1

Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (672 aa)

Predicted Functional Partners:

EXTL3

0.928

CHPF2

0.774

DDIT4L

0.769

EXT2

0.761

EOGT

0.735

MAN2C1

0.677

EXTL2

0.616

B4GALT1

0.614

ARHGEF2

0.578

SCN3B

0.567

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	EXTL1	ENSCAFP00000057462	ENSCAFP00000018700	Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...]	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.578
B4GALT1	CHPF2	ENSCAFP00000002691	ENSCAFP00000048448	Beta-1,4-galactosyltransferase 1.	Hexosyltransferase.	0.522
B4GALT1	EOGT	ENSCAFP00000002691	ENSCAFP00000009819	Beta-1,4-galactosyltransferase 1.	EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family.	0.569
B4GALT1	EXTL1	ENSCAFP00000002691	ENSCAFP00000018700	Beta-1,4-galactosyltransferase 1.	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.614
B4GALT1	EXTL2	ENSCAFP00000002691	ENSCAFP00000029639	Beta-1,4-galactosyltransferase 1.	Exostosin like glycosyltransferase 2.	0.506
B4GALT1	MAN2C1	ENSCAFP00000002691	ENSCAFP00000046556	Beta-1,4-galactosyltransferase 1.	Mannosidase alpha class 2C member 1.	0.554
CHPF2	B4GALT1	ENSCAFP00000048448	ENSCAFP00000002691	Hexosyltransferase.	Beta-1,4-galactosyltransferase 1.	0.522
CHPF2	EOGT	ENSCAFP00000048448	ENSCAFP00000009819	Hexosyltransferase.	EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family.	0.770
CHPF2	EXTL1	ENSCAFP00000048448	ENSCAFP00000018700	Hexosyltransferase.	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.774
CHPF2	EXTL2	ENSCAFP00000048448	ENSCAFP00000029639	Hexosyltransferase.	Exostosin like glycosyltransferase 2.	0.482
CHPF2	MAN2C1	ENSCAFP00000048448	ENSCAFP00000046556	Hexosyltransferase.	Mannosidase alpha class 2C member 1.	0.707
DDIT4L	EXTL1	ENSCAFP00000042338	ENSCAFP00000018700	DNA damage inducible transcript 4 like.	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.769
DDIT4L	SCN3B	ENSCAFP00000042338	ENSCAFP00000057747	DNA damage inducible transcript 4 like.	Sodium voltage-gated channel beta subunit 3.	0.614
EOGT	B4GALT1	ENSCAFP00000009819	ENSCAFP00000002691	EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family.	Beta-1,4-galactosyltransferase 1.	0.569
EOGT	CHPF2	ENSCAFP00000009819	ENSCAFP00000048448	EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family.	Hexosyltransferase.	0.770
EOGT	EXTL1	ENSCAFP00000009819	ENSCAFP00000018700	EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family.	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.735
EOGT	MAN2C1	ENSCAFP00000009819	ENSCAFP00000046556	EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family.	Mannosidase alpha class 2C member 1.	0.764
EXT2	EXTL1	ENSCAFP00000013939	ENSCAFP00000018700	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family.	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.761
EXTL1	ARHGEF2	ENSCAFP00000018700	ENSCAFP00000057462	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...]	0.578
EXTL1	B4GALT1	ENSCAFP00000018700	ENSCAFP00000002691	Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	Beta-1,4-galactosyltransferase 1.	0.614