STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXW12F-box and WD repeat domain containing 12. (463 aa)    
Predicted Functional Partners:
MNAT1
MNAT1 component of CDK activating kinase.
   
 
 0.797
CCNH
Cyclin H; Belongs to the cyclin family.
   
 
 0.794
GTF2H3
General transcription factor IIH subunit 3.
   
 
 0.791
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
   
 
 0.789
POLR2A
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.788
GTF2E2
Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
   
 
 0.779
GTF2H2
General transcription factor IIH subunit.
   
 
 0.770
GTF2H1
General transcription factor IIH subunit 1.
   
 
 0.762
GTF2E1
General transcription factor IIE subunit 1.
    
 
 0.760
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
    
 
 0.746
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.