STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDC25ACell division cycle 25A. (524 aa)    
Predicted Functional Partners:
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.989
CHEK1
Checkpoint kinase 1.
   
 0.984
PLK1
Serine/threonine-protein kinase PLK.
   
 0.979
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.975
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.972
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.972
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.968
CCNB1
Uncharacterized protein; Belongs to the cyclin family.
   
 0.962
CCND1
G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]
   
 
 0.961
CCNB2
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
 0.957
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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