STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CNR2Cannabinod receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)    
Predicted Functional Partners:
CNR1
Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...]
  
 
0.932
GPR55
G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family.
     
 0.755
GPR18
G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family.
   
 0.682
NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D.
      
 0.608
FAAH
Fatty acid amide hydrolase.
   
  
 0.604
HCAR2
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
     
 0.563
SIT1
Signaling threshold regulating transmembrane adaptor 1.
   
  
 0.562
ABHD6
Abhydrolase domain containing 6.
   
  
 0.550
GPR183
G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.547
GALK1
Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily.
      
 0.543
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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