STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SP3Sp3 transcription factor. (716 aa)    
Predicted Functional Partners:
PAX4
Paired box 4.
    
 
 0.751
WDR92
WD repeat domain 92.
   
 
 0.734
SP1
Sp1 transcription factor.
   
 
0.664
PPP1CC
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...]
   
 
 0.648
PROKR1
Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family.
      
 0.610
SUZ12
SUZ12 polycomb repressive complex 2 subunit.
   
 
 0.606
STAG2
Stromal antigen 2.
   
   0.564
SMAD3
Mothers against decapentaplegic homolog.
    
 
 0.543
ETAA1
ETAA1 activator of ATR kinase.
   
 
 0.527
SP9
Sp9 transcription factor.
 
    
 0.523
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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