STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SETD2SET domain containing 2, histone lysine methyltransferase. (2562 aa)    
Predicted Functional Partners:
POLR2A
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.940
LOC111090006
Histone H3; Belongs to the histone H3 family.
   
 0.883
LOC488263
Histone H3; Belongs to the histone H3 family.
   
 0.883
ASH1L
ASH1 like histone lysine methyltransferase.
   
  
0.879
NIPBL
Nipped-B protein.
   
  
 0.872
POLR2B
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.855
BPTF
Bromodomain PHD finger transcription factor.
   
 
 0.843
POLR2C
RNA polymerase II subunit C.
   
 
 0.841
USP34
Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.
   
 
 0.839
PBRM1
Polybromo 1.
   
 
 0.802
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.